TY  - JOUR
AU  - Wurschi, Georg
AU  - Kesselmeier, Miriam
AU  - Schneider, Melanie
AU  - Becker, Jan-Niklas
AU  - Frerker, Bernd
AU  - Vorbach, Samuel M
AU  - Ehret, Felix
AU  - Diefenhardt, Markus
AU  - Schunn, Fabian
AU  - von Gruben, Maria-Elena
AU  - Büttner, Marcel
AU  - Hoffmann, Elgin
AU  - Rühle, Alexander
AU  - Beier, Josephine
AU  - Ferdinandus, Simone
AU  - Trommer, Maike
AU  - Sahin, Ezgi Ceren
AU  - Hlouschek, Julian
AU  - Aninditha, Kynann
AU  - von Ohlen, Daphne Schepers
AU  - Kaufmann, Justus
AU  - Depardon, Alina
AU  - Ha, Hai Minh
AU  - Trommer, Simon
AU  - Kessler, Christopher
AU  - Cieslak, Adrianna
AU  - Fabian, Alexander
AU  - Rißner, Florian
AU  - Römer, Maximilian
AU  - Mäurer, Matthias
AU  - Pietschmann, Klaus
TI  - Short-course radiotherapy versus long-course chemoradiotherapy in total neoadjuvant therapy of rectal cancer - A multicenter analysis of early outcomes and toxicity.
JO  - Radiotherapy and oncology
VL  - 213
SN  - 0167-8140
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DKFZ-2025-02093
SP  - 111194
PY  - 2025
N1  - 2025 Dec;213:111194
AB  - Total neoadjuvant therapy (TNT) improves local control and complete response (CR) rates in locally advanced rectal cancer (LARC). CR is associated with favorable local tumor control, allowing non-operative management (NOM). However, it remains unclear whether short-course radiotherapy (SCRT) or long-course chemoradiotherapy (LCRT) is preferable within TNT.LARC patients undergoing TNT between 2015 and 2024 were included in this retrospective multicenter analysis (DRKS00033000). The primary endpoint was CR. Secondary endpoints comprised NOM rates, toxicity, and tumor control. Multivariable logistic regression modelling was used to assess the influence of LCRT.Of 295 included patients with a median age at diagnosis of 62 (Q1-Q3: 54-68) years and 210 (71.2 
KW  - Chemoradiotherapy (Other)
KW  - Complete response (Other)
KW  - Rectal cancer (Other)
KW  - Total neoadjuvant therapy (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:41077142
DO  - DOI:10.1016/j.radonc.2025.111194
UR  - https://inrepo02.dkfz.de/record/305349
ER  -