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000305358 1001_ $$aTaylor, Sarah A$$b0
000305358 245__ $$aTowards a reference cell atlas of liver diversity over the human lifespan.
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000305358 500__ $$a2026 Jan;23(1):97-109. doi: 10.1038/s41575-025-01114-3. Epub 2025 Oct 13
000305358 520__ $$aThe goal of the Human Liver Cell Atlas (HLiCA) is to create a comprehensive map that defines the normal functions of diverse liver cell types and their spatial relationships over the human lifespan. This project fits within the goals of the Human Cell Atlas to create comprehensive reference maps of all human cells as a basis for both understanding human health and diagnosing, monitoring and treating disease. Through collection of samples from diverse individuals, data integration across technologies and overcoming liver-specific challenges for experimental methods, the HLiCA will map as many cell types and states as possible in healthy human livers from individuals across all ages and many ancestries. Establishing this HLiCA of healthy livers is a critical step to begin to understand perturbations in disease. The HLiCA will be available on an open-access platform to facilitate data sharing and dissemination. We expect that creation of the HLiCA will help to lay the foundation for new research initiatives to advance our understanding of liver disease, improve methods of tissue engineering, and identify novel prognostic biomarkers and therapies to improve patient outcomes. We describe key experimental and computational challenges to overcome in building the atlas and the potential impact of the atlas on disease research.
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000305358 7001_ $$00000-0003-0185-8861$$aBader, Gary D$$b1
000305358 7001_ $$aMacParland, Sonya$$b2
000305358 7001_ $$00000-0002-4096-3106$$aMullen, Alan C$$b3
000305358 7001_ $$00000-0003-1120-2196$$aAndrews, Tallulah$$b4
000305358 7001_ $$aCuenca, Alex G$$b5
000305358 7001_ $$00000-0001-9015-3729$$aDasGupta, Ramanuj$$b6
000305358 7001_ $$aGehring, Adam J$$b7
000305358 7001_ $$00000-0002-3364-5898$$aGrün, Dominic$$b8
000305358 7001_ $$aGuilliams, Martin$$b9
000305358 7001_ $$aGulamhusein, Aliya$$b10
000305358 7001_ $$00000-0002-2273-4094$$aHenderson, Neil C$$b11
000305358 7001_ $$aHirschfield, Gideon$$b12
000305358 7001_ $$00000-0003-3977-8728$$aHuppert, Stacey S$$b13
000305358 7001_ $$00000-0003-0685-2522$$aItzkovitz, Shalev$$b14
000305358 7001_ $$aJiang, Z Gordon$$b15
000305358 7001_ $$00000-0002-9792-4271$$aLauer, Georg M$$b16
000305358 7001_ $$aMcGilvray, Ian$$b17
000305358 7001_ $$00000-0001-9890-5518$$aMysore, Krupa R$$b18
000305358 7001_ $$00000-0001-8234-4058$$aPirola, Carlos J$$b19
000305358 7001_ $$aQuon, Gerald$$b20
000305358 7001_ $$0P:(DE-He78)8757fd490dcfe2d6c4b1c2b126262468$$aRahbari, Mohammad$$b21$$udkfz
000305358 7001_ $$aRegev, Aviv$$b22
000305358 7001_ $$aRicciuto, Amanda$$b23
000305358 7001_ $$aScott, Charlotte L$$b24
000305358 7001_ $$aSharma, Ankur$$b25
000305358 7001_ $$00000-0001-5929-5470$$aSookoian, Silvia$$b26
000305358 7001_ $$00000-0002-3665-2735$$aTana, Michelle M$$b27
000305358 7001_ $$aTeichmann, Sarah A$$b28
000305358 7001_ $$00000-0002-3848-2602$$aVallier, Ludovic$$b29
000305358 7001_ $$aVlachos, Ioannis S$$b30
000305358 7001_ $$aWang, Bruce$$b31
000305358 7001_ $$aZhen, Mei$$b32
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