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@ARTICLE{Melchers:305365,
      author       = {S. Melchers$^*$ and L. Tengler and Ö. C. Sener$^*$ and P.
                      L. Beltzig$^*$ and R. Schmidt and S. Klein and J. S.
                      Utikal$^*$ and J. Nicolay$^*$},
      title        = {{E}xtracorporeal photopheresis therapy rapidly changes the
                      cytokine profile and tumor microenvironment in cutaneous {T}
                      cell lymphoma.},
      journal      = {Frontiers in immunology},
      volume       = {16},
      issn         = {1664-3224},
      address      = {Lausanne},
      publisher    = {Frontiers Media},
      reportid     = {DKFZ-2025-02109},
      pages        = {1669015},
      year         = {2025},
      note         = {#EA:A370#LA:A370#},
      abstract     = {Primary cutaneous T cell lymphomas (CTCL) are a
                      heterogeneous group of rare lymphoproliferative disorders
                      originating in the skin. Extracorporeal photopheresis (ECP)
                      is an established, effective and excellently tolerable CTCL
                      therapy, that can also be applied for the treatment of graft
                      vs. host disease (GvHD). However, the underlying molecular
                      mechanisms of ECP have not yet been fully clarified and seem
                      to be dependent on the underlying disease. In this study,
                      peripheral blood samples collected from six CTCL and three
                      GvHD patients were analyzed pre- and post-ECP within one
                      treatment of ECP for short-term alterations in the cytokine
                      and chemokine milieu in the plasma and the composition of
                      the peripheral blood mononuclear cell (PBMC) subsets. In
                      CTCL, the plasma profiling revealed a lower expression of
                      IL-15, IL-17, ICOS and higher expression of IL-13 post-ECP
                      compared to the pre-ECP samples. Additionally, ECP led to an
                      increased expression of the cell death inducers Fas and
                      TRAIL. Flow cytometry revealed a significant increase in the
                      CD14+ monocytes post-ECP in the CTCL patients, and a
                      tendency of higher CD3+CD4- cytotoxic T cells in GvHD
                      patient. Therefore, one cycle of ECP can induce detectable
                      alterations in the peripheral blood of both CTCL and GvHD
                      patients. This study contributes to the elucidation of the
                      molecular mechanisms of ECP therapy and the detection of
                      potential biomarkers for therapeutic response to ECP.},
      keywords     = {Humans / Photopheresis: methods / Lymphoma, T-Cell,
                      Cutaneous: therapy / Lymphoma, T-Cell, Cutaneous: immunology
                      / Lymphoma, T-Cell, Cutaneous: blood / Lymphoma, T-Cell,
                      Cutaneous: pathology / Cytokines: blood / Cytokines:
                      metabolism / Middle Aged / Male / Female / Tumor
                      Microenvironment: immunology / Graft vs Host Disease:
                      therapy / Graft vs Host Disease: immunology / Skin
                      Neoplasms: therapy / Skin Neoplasms: immunology / Skin
                      Neoplasms: blood / Skin Neoplasms: pathology / Aged / Adult
                      / Sézary syndrome (Other) / cutaneous T cell lymphoma
                      (Other) / extracorporeal photopheresis (Other) /
                      graft-versus-host-disease (Other) / transimmunization
                      (Other) / Cytokines (NLM Chemicals)},
      cin          = {A370},
      ddc          = {610},
      cid          = {I:(DE-He78)A370-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41080600},
      pmc          = {pmc:PMC12507584},
      doi          = {10.3389/fimmu.2025.1669015},
      url          = {https://inrepo02.dkfz.de/record/305365},
}