TY  - JOUR
AU  - Peng, Lei
AU  - Xie, Ruijie
AU  - Holleczek, Bernd
AU  - Brenner, Hermann
AU  - Schöttker, Ben
TI  - Development of Age- and Sex-Specific Metabolomics-Based Biological Ageing Clocks for 10-Year Mortality Prediction.
JO  - Advanced science
VL  - nn
SN  - 2198-3844
CY  - Weinheim
PB  - Wiley-VCH
M1  - DKFZ-2025-02138
SP  - nn
PY  - 2025
N1  - #EA:C070#LA:C070# / epub
AB  - Metabolite concentrations vary by age and sex, yet age- and sex-specific metabolomic risk scores and biological ageing clocks for mortality prediction remain undeveloped. Nuclear magnetic resonance (NMR)-based metabolomic profiling is conducted in 209144 UK Biobank participants (12347 deaths) and 6820 from the German ESTHER study (804 deaths). Mortality risk scores are derived using least absolute shrinkage and selection operator (LASSO)-regularized Cox regression, and metabolomics-based mortality risk clocks (MetaboMR clocks) are constructed using elastic net regression in sex- and age-stratified subgroups (50-59 and 60-69 years). Models are trained in 70
KW  - all‐cause mortality (Other)
KW  - cohort studies (Other)
KW  - metabolomic age acceleration (Other)
KW  - metabolomics (Other)
KW  - risk prediction (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:41092367
DO  - DOI:10.1002/advs.202510189
UR  - https://inrepo02.dkfz.de/record/305401
ER  -