%0 Journal Article
%A Wittenstein, Jakob
%A Apolle, Rudi
%A Scharffenberg, Martin
%A Rothmann, Carolin
%A Müller, Sabine
%A Hoffmann, Ralf-Thorsten
%A Troost, Esther
%A Koch, Thea
%A Gama de Abreu, Marcelo
%A Huhle, Robert
%T Dual-energy computed tomography derived pulmonary blood volume: association with pulmonary blood flow.
%J Respiratory research
%V 26
%N 1
%@ 1465-9921
%C London
%I BioMed Central
%M DKFZ-2025-02203
%P 293
%D 2025
%X Distribution of ventilation and pulmonary perfusion are the major determinants of pulmonary gas exchange. To study and compare strategies of mechanical ventilation in respiratory research accurate and high-resolution methods are needed to derive distribution of ventilation and perfusion with minimal additional intervention or radiation allowing repeated measurements. Dual-energy computed tomography (DECT) is an imaging technique allowing for the derivation of regional pulmonary perfused blood volume, as a surrogate for pulmonary perfusion (PPDECT). Here accuracy of PPDECT is evaluated in comparison to pulmonary blood flow measured with fluorescence-labeled microspheres (PPFLM). Its feasibility of repeated measurements is evaluated.Agreement between PPFLM and PPDECT was assessed by regression as well as Bland-Altman analysis in three anesthetized pigs using DECT and fluorescence labelled microspheres, respectively. Measurements were performed in two-lung and, after right sided thoracotomy, at one-lung ventilation with inhaled nitric oxide. PPFLM and PPDECT were assessed in three different regions of interest (ROI): the right (non-ventilated) and left (ventilated) upper and lower lung, yielding a total of 45 paired measurements over four hours. Persistent iodine accumulation was assessed by additional DECT scans before each contrast administration.Regression analysis revealed a good overall association (R2 = 0.81) between PPFLM and PPDECT, with PPDECT substantially overestimating PPFLM up to 30
%K Animals
%K Swine
%K Pulmonary Circulation: physiology
%K Lung: diagnostic imaging
%K Lung: blood supply
%K Lung: physiology
%K Blood Volume: physiology
%K Tomography, X-Ray Computed: methods
%K Female
%K Radiography, Dual-Energy Scanned Projection: methods
%K Feasibility Studies
%K Dual-energy CT (Other)
%K Fluorescence labelled microspheres (Other)
%K Regional pulmonary perfusion (Other)
%K Shunt blood flow (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41126267
%2 pmc:PMC12548200
%R 10.1186/s12931-025-03374-8
%U https://inrepo02.dkfz.de/record/305519