TY  - JOUR
AU  - Wittenstein, Jakob
AU  - Apolle, Rudi
AU  - Scharffenberg, Martin
AU  - Rothmann, Carolin
AU  - Müller, Sabine
AU  - Hoffmann, Ralf-Thorsten
AU  - Troost, Esther
AU  - Koch, Thea
AU  - Gama de Abreu, Marcelo
AU  - Huhle, Robert
TI  - Dual-energy computed tomography derived pulmonary blood volume: association with pulmonary blood flow.
JO  - Respiratory research
VL  - 26
IS  - 1
SN  - 1465-9921
CY  - London
PB  - BioMed Central
M1  - DKFZ-2025-02203
SP  - 293
PY  - 2025
AB  - Distribution of ventilation and pulmonary perfusion are the major determinants of pulmonary gas exchange. To study and compare strategies of mechanical ventilation in respiratory research accurate and high-resolution methods are needed to derive distribution of ventilation and perfusion with minimal additional intervention or radiation allowing repeated measurements. Dual-energy computed tomography (DECT) is an imaging technique allowing for the derivation of regional pulmonary perfused blood volume, as a surrogate for pulmonary perfusion (PPDECT). Here accuracy of PPDECT is evaluated in comparison to pulmonary blood flow measured with fluorescence-labeled microspheres (PPFLM). Its feasibility of repeated measurements is evaluated.Agreement between PPFLM and PPDECT was assessed by regression as well as Bland-Altman analysis in three anesthetized pigs using DECT and fluorescence labelled microspheres, respectively. Measurements were performed in two-lung and, after right sided thoracotomy, at one-lung ventilation with inhaled nitric oxide. PPFLM and PPDECT were assessed in three different regions of interest (ROI): the right (non-ventilated) and left (ventilated) upper and lower lung, yielding a total of 45 paired measurements over four hours. Persistent iodine accumulation was assessed by additional DECT scans before each contrast administration.Regression analysis revealed a good overall association (R2 = 0.81) between PPFLM and PPDECT, with PPDECT substantially overestimating PPFLM up to 30
KW  - Animals
KW  - Swine
KW  - Pulmonary Circulation: physiology
KW  - Lung: diagnostic imaging
KW  - Lung: blood supply
KW  - Lung: physiology
KW  - Blood Volume: physiology
KW  - Tomography, X-Ray Computed: methods
KW  - Female
KW  - Radiography, Dual-Energy Scanned Projection: methods
KW  - Feasibility Studies
KW  - Dual-energy CT (Other)
KW  - Fluorescence labelled microspheres (Other)
KW  - Regional pulmonary perfusion (Other)
KW  - Shunt blood flow (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:41126267
C2  - pmc:PMC12548200
DO  - DOI:10.1186/s12931-025-03374-8
UR  - https://inrepo02.dkfz.de/record/305519
ER  -