TY  - JOUR
AU  - Barendsz, Laura J C
AU  - Sumser, Kemal
AU  - Gerhalter, Teresa
AU  - Mestrom, Rob M C
AU  - Nagel, Armin
AU  - Paulides, Margarethus M
TI  - Ticept: Wideband Electrical Properties Tomography by Tissue Composition Assessment With Quantitative <sup>1</sup>H<sup>23</sup>Na<sup>39</sup>K Multinuclear MRI.
JO  - Magnetic resonance in medicine
VL  - 95
IS  - 3
SN  - 1522-2594
CY  - New York, NY [u.a.]
PB  - Wiley-Liss
M1  - DKFZ-2025-02207
SP  - 1503-1512
PY  - 2026
N1  - 2026 Mar;95(3):1503-1512. doi: 10.1002/mrm.70139. Epub 2025 Oct 24
AB  - To develop a noninvasive method for estimating dielectric properties over a wide frequency range from 50 to 600 MHz. Existing methods are limited in accuracy and provide single-frequency results. Furthermore, accurate knowledge of dielectric properties becomes more important, since medical device design and safety evaluation increasingly rely on computational modeling-based evaluation.Tissue composition assessment was performed to find the most important factors for the dielectric properties, which were sodium, potassium, and water. These were measured with a 3D acquisition-weighted density-adapted stack-of-stars scheme (<sup>23</sup> Na and <sup>39</sup> K) and an inversion recovery turbo spin echo sequence (<sup>1</sup>H). Measurements were conducted in muscle-representative phantoms and six healthy volunteers. These measurements were used as input for mixture models, which were used to correlate the dielectric properties of the mixture with its constituents. Four different mixture models were tested to assess the feasibility of this method.With the Maxwell-Garnett mixture model, a 7.9
KW  - electrical conductivity (Other)
KW  - electrical properties tomography (EPT) (Other)
KW  - mixture theory (Other)
KW  - permittivity (Other)
KW  - potassium MRI (Other)
KW  - sodium MRI (Other)
KW  - tissue water content (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:41133303
DO  - DOI:10.1002/mrm.70139
UR  - https://inrepo02.dkfz.de/record/305533
ER  -