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000305536 0247_ $$2ISSN$$a2050-6414
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000305536 1001_ $$00000-0003-1197-0419$$aVornhülz, Marlies$$b0
000305536 245__ $$aCommon Practice of Percutaneous Drainage in Necrotising Pancreatitis-A Multicentre Retrospective Study (DRACULA).
000305536 260__ $$aHoboken, NJ$$bWiley$$c2025
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000305536 520__ $$aAcute necrotising pancreatitis carries high mortality, especially if infected necrosis occurs. While percutaneous drainage may be required when internal drainage is not feasible, reliable guidelines for managing percutaneous drains are lacking. This study aimed to assess the common practice of percutaneous drainage therapy for infected pancreatic necrosis.This retrospective study among 29 tertiary care centres included all patients hospitalised for necrotising acute pancreatitis from 01/2016 until 12/2022 with at least one percutaneous drain. The length of hospital stay was the primary endpoint, with mortality as the secondary endpoint. Between-group comparisons were conducted using the ratio of restricted mean survival time (RMST) after adjusting for confounders.585 patients (67% male) from 29 tertiary care centres in 15 countries in Europe, Canada and Bolivia were included in the analysis. Length of hospitalisation or mortality did not differ between the flushed (n = 398) and non-flushed groups (RMST ratio 1.04, p-value = 0.42 and RMST ratio 1.05, p-value = 0.1 respectively). Mortality was significantly lower in those patients who received a combination of percutaneous and internal drains (dual-modality drainage, n = 243) as compared to those who received percutaneous drains only (RMST ratio 1.05, p-value = 0.01). Flushing with antibiotics as compared to saline was not associated with shorter length of hospital stay or lower mortality (RMST ratio 0.98, p-value = 0.78 and 0.97, p-value = 0.48 respectively).This study reveals notable differences in therapeutic concepts and flushing management for percutaneous drains. While flushing itself was not associated with a shorter length of hospitalisation or lower in-hospital mortality, a lower mortality was observed when internal and percutaneous drainage were used in combination.The study was prospectively registered in the German Clinical Trials Register (Deutsches Register Klinischer Studien, DRKS) under the registration number DRKS00032231.
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000305536 650_7 $$2Other$$adrainage
000305536 650_7 $$2Other$$aflushing
000305536 650_7 $$2Other$$anecrosis
000305536 650_7 $$2Other$$apancreatitis
000305536 7001_ $$00000-0002-6047-334X$$aSirtl, Simon$$b1
000305536 7001_ $$00000-0002-8487-7584$$aXu, Yujun$$b2
000305536 7001_ $$00000-0003-3002-7848$$aKlauss, Sarah$$b3
000305536 7001_ $$00000-0003-1904-2553$$aOrgler-Gasche, Elisabeth$$b4
000305536 7001_ $$00000-0003-1938-8298$$aBezmarevic, Mihailo$$b5
000305536 7001_ $$aJovanovic, Milan$$b6
000305536 7001_ $$00000-0002-6638-4479$$aRicci, Claudio$$b7
000305536 7001_ $$aFernandez Y Viesca, Michael$$b8
000305536 7001_ $$aArvanitakis, Marianna$$b9
000305536 7001_ $$00000-0002-9481-6021$$aHadi, Amer$$b10
000305536 7001_ $$00000-0002-3359-6061$$aPrahm, August Pilegaard$$b11
000305536 7001_ $$00000-0003-2348-5664$$aDi Mauro, Davide$$b12
000305536 7001_ $$00000-0003-4371-2246$$aRuess, Dietrich A$$b13
000305536 7001_ $$00009-0007-4024-0358$$aFocke, Carola$$b14
000305536 7001_ $$aBender, Fabienne$$b15
000305536 7001_ $$00000-0003-4960-6858$$aHamm, Jacob$$b16
000305536 7001_ $$00009-0009-2465-8927$$aAmmer-Herrmenau, Christoph$$b17
000305536 7001_ $$00000-0001-5540-6452$$aGonçalves, Tiago Cúrdia$$b18
000305536 7001_ $$00000-0002-4081-8072$$aGonçalves, João Carlos$$b19
000305536 7001_ $$00009-0007-8279-1799$$aCalavrezos, Lenika$$b20
000305536 7001_ $$00000-0003-4368-2016$$aGötz, Mara$$b21
000305536 7001_ $$aStoerzer, Simon$$b22
000305536 7001_ $$aSchmelzle, Moritz$$b23
000305536 7001_ $$aNawacki, Łukasz$$b24
000305536 7001_ $$aCondori, Carlos$$b25
000305536 7001_ $$aSeitzinger, Max$$b26
000305536 7001_ $$00000-0001-6081-2316$$aSeelig, Julian$$b27
000305536 7001_ $$00000-0002-3503-8450$$aChooklin, Serge$$b28
000305536 7001_ $$aChuklin, Serhii$$b29
000305536 7001_ $$00000-0002-7917-8017$$aRasch, Sebastian$$b30
000305536 7001_ $$aPhillip, Veit$$b31
000305536 7001_ $$00000-0003-3099-2197$$aPandanaboyana, Sanjay$$b32
000305536 7001_ $$aAljaberi, Rami$$b33
000305536 7001_ $$00000-0002-9008-2358$$aKuzman, Matta$$b34
000305536 7001_ $$00000-0002-6801-4076$$aMeinhardt, Christian$$b35
000305536 7001_ $$aGonzález de la Higuera Carnicer, Belén$$b36
000305536 7001_ $$aRuiz-Clavijo García, David$$b37
000305536 7001_ $$00000-0003-3658-8427$$aEross, Bálint$$b38
000305536 7001_ $$00000-0003-0399-7259$$aHegyi, Peter$$b39
000305536 7001_ $$00000-0002-7722-9896$$aKerbazh, Nizar$$b40
000305536 7001_ $$aMoga, Tudor Voicu$$b41
000305536 7001_ $$00000-0002-0771-1177$$aPawlak, Katarzyna$$b42
000305536 7001_ $$aCalo, Natalia$$b43
000305536 7001_ $$00000-0002-5534-7533$$aKhalaf, Kareem$$b44
000305536 7001_ $$aBrunner, Maximilian$$b45
000305536 7001_ $$aSchulte, Lucas$$b46
000305536 7001_ $$00000-0003-0592-5232$$aKleger, Alexander$$b47
000305536 7001_ $$00000-0003-4600-9257$$aRuiz Rebollo, María Lourdes$$b48
000305536 7001_ $$aSeidensticker, Max$$b49
000305536 7001_ $$aWildgruber, Moritz$$b50
000305536 7001_ $$00000-0002-9955-8906$$aMansmann, Ulrich$$b51
000305536 7001_ $$00000-0002-7873-996X$$aStubbe, Hans$$b52
000305536 7001_ $$00000-0002-3666-6459$$aMayerle, Julia$$b53
000305536 7001_ $$00000-0002-7607-8264$$aBeyer, Georg$$b54
000305536 7001_ $$aDRACULA study group: Laszlo Czako, Valentina Ratkajec$$b55$$eCollaboration Author
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