%0 Journal Article
%A Brenner, Hermann
%A Holland-Letz, Tim
%A Kopp-Schneider, Annette
%A Heisser, Thomas
%A Hoffmeister, Michael
%T Early-detection and prevention effects of screening sigmoidoscopy: evidence from randomized trials revisited.
%J Journal of the National Cancer Institute
%V nn
%@ 0027-8874
%C Oxford
%I Oxford Univ. Press
%M DKFZ-2025-02244
%P nn
%D 2025
%Z ISSN 1460-2105 / #EA:M320#LA:C070# / epub
%X Large-scale randomized controlled trials (RCTs) have established compelling evidence that screening by flexible sigmoidoscopy reduces colorectal cancer (CRC) incidence. Reported incidence results include cancers that were already prevalent and yet undiagnosed, but no longer preventable at screening. We aimed to derive, disentangle and fully disclose early-detection and long-term prevention effects of screening sigmoidoscopy from published trial results.We used data from three large-scale RCTs from the United Kingdom (UKFSST), Italy (SCORE) and the US (PLCO), which included a total number of 359,198 participants. For each trial and each length of follow-up, we derived the numbers and proportions of CRC cases that were either early detected or prevented among screening attenders.In the UKFSST, which reported the longest follow-up data, screening sigmoidoscopy prevented 64
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41165595
%R 10.1093/jnci/djaf313
%U https://inrepo02.dkfz.de/record/305585