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000305587 041__ $$aEnglish
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000305587 1001_ $$aVasson, Fanélie$$b0
000305587 245__ $$aLifestyle changes and postmenopausal breast cancer risk in women from the European Prospective Investigation into Cancer and Nutrition.
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000305587 520__ $$aThe risk of breast cancer has been associated with various lifestyle factors, yet the evidence regarding how lifestyle modifications affect this risk remains limited. This study examines the relationship between changes in the Healthy Lifestyle Index (HLI) and postmenopausal breast cancer risk in women participating in the European Prospective Investigation into Cancer (EPIC).HLI scores (ranging from 0 to 16) were computed based on smoking habits, alcohol consumption, body mass index (BMI), and physical activity levels, using data from baseline and follow-up questionnaires, which were separated by a median interval of 10 (IQR: 5.2-12.0) years. Among the 125,746 women included in the analyses, 2,175 developed breast cancer over a median follow-up period of nearly 4 (IQR: 2.9-8.4) years starting from the date of the second lifestyle questionnaire. Cox proportional hazards models were employed to estimate hazard ratios (HRs) and confidence intervals (CIs) for the relationship between changes in HLI and postmenopausal breast cancer risk, analysed both overall and by estrogen receptor (ER) status. Individual components of the HLI were also analysed, with sensitivity analyses addressing potential reverse causation by delaying the start of follow-up by 1 to 3 years.Each unit increase in the HLI-reflecting a healthier lifestyle-was not associated with the overall risk of postmenopausal breast cancer. Among individual components, only a one-unit increase in the BMI score, corresponding to a shift towards a healthier BMI, was inversely associated with overall (HR = 0.936; 95% CI 0.880-0.996) and ER-positive (HR = 0.930; 95% CI 0.865-1.000) postmenopausal breast cancer risks.Lifestyle changes, as measured by the HLI, during mid-adulthood were not significantly associated with the risk of postmenopausal breast cancer. More specifically, the results of this study suggested that a shift towards a healthier BMI may contribute to breast cancer prevention. Further research involving diverse and larger study populations and lifestyle assessments at earlier life stages could provide deeper insights.
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000305587 650_7 $$2Other$$aBreast cancer
000305587 650_7 $$2Other$$aHealthy lifestyle index
000305587 650_7 $$2Other$$aLifestyle changes
000305587 650_7 $$2Other$$aLongitudinal
000305587 650_7 $$2Other$$aProspective cohort
000305587 650_7 $$2Other$$aRisk
000305587 650_7 $$2NLM Chemicals$$aReceptors, Estrogen
000305587 650_2 $$2MeSH$$aHumans
000305587 650_2 $$2MeSH$$aFemale
000305587 650_2 $$2MeSH$$aBreast Neoplasms: epidemiology
000305587 650_2 $$2MeSH$$aBreast Neoplasms: etiology
000305587 650_2 $$2MeSH$$aPostmenopause
000305587 650_2 $$2MeSH$$aMiddle Aged
000305587 650_2 $$2MeSH$$aEurope: epidemiology
000305587 650_2 $$2MeSH$$aLife Style
000305587 650_2 $$2MeSH$$aRisk Factors
000305587 650_2 $$2MeSH$$aProspective Studies
000305587 650_2 $$2MeSH$$aAged
000305587 650_2 $$2MeSH$$aBody Mass Index
000305587 650_2 $$2MeSH$$aSurveys and Questionnaires
000305587 650_2 $$2MeSH$$aProportional Hazards Models
000305587 650_2 $$2MeSH$$aExercise
000305587 650_2 $$2MeSH$$aReceptors, Estrogen: metabolism
000305587 650_2 $$2MeSH$$aFollow-Up Studies
000305587 7001_ $$aMatta, Komodo$$b1
000305587 7001_ $$aBiessy, Carine$$b2
000305587 7001_ $$aS Antoniussen, Christian$$b3
000305587 7001_ $$aFournier, Agnès$$b4
000305587 7001_ $$aMarques, Chloé$$b5
000305587 7001_ $$aCadeau, Claire$$b6
000305587 7001_ $$0P:(DE-He78)2d4cac0f4bf270325b98fe07036dc6c6$$aLe Cornet, Charlotte$$b7$$udkfz
000305587 7001_ $$0P:(DE-HGF)0$$aT Fortner, Renée$$b8
000305587 7001_ $$aSchulze, Matthias B$$b9
000305587 7001_ $$aSieri, Sabina$$b10
000305587 7001_ $$aPanico, Salvatore$$b11
000305587 7001_ $$aTumino, Rosario$$b12
000305587 7001_ $$aRicceri, Fulvio$$b13
000305587 7001_ $$aMasala, Giovanna$$b14
000305587 7001_ $$aHiensch, Anouk E$$b15
000305587 7001_ $$aMonninkhof, Evelyn M$$b16
000305587 7001_ $$aAgudo, Antonio$$b17
000305587 7001_ $$aGuevara, Marcela$$b18
000305587 7001_ $$aColorado-Yohar, Sandra M$$b19
000305587 7001_ $$aSánchez, Maria-José$$b20
000305587 7001_ $$aLlorente, Adrian$$b21
000305587 7001_ $$aTin Tin, Sandar$$b22
000305587 7001_ $$aJackson, Isobel G$$b23
000305587 7001_ $$aGunter, Marc J$$b24
000305587 7001_ $$aBotteri, Edoardo$$b25
000305587 7001_ $$aFerrari, Pietro$$b26
000305587 7001_ $$aDossus, Laure$$b27
000305587 773__ $$0PERI:(DE-600)2041618-0$$a10.1186/s13058-025-02148-w$$gVol. 27, no. 1, p. 192$$n1$$p192$$tBreast cancer research$$v27$$x1465-5411$$y2025
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