TY  - JOUR
AU  - Vasson, Fanélie
AU  - Matta, Komodo
AU  - Biessy, Carine
AU  - S Antoniussen, Christian
AU  - Fournier, Agnès
AU  - Marques, Chloé
AU  - Cadeau, Claire
AU  - Le Cornet, Charlotte
AU  - T Fortner, Renée
AU  - Schulze, Matthias B
AU  - Sieri, Sabina
AU  - Panico, Salvatore
AU  - Tumino, Rosario
AU  - Ricceri, Fulvio
AU  - Masala, Giovanna
AU  - Hiensch, Anouk E
AU  - Monninkhof, Evelyn M
AU  - Agudo, Antonio
AU  - Guevara, Marcela
AU  - Colorado-Yohar, Sandra M
AU  - Sánchez, Maria-José
AU  - Llorente, Adrian
AU  - Tin Tin, Sandar
AU  - Jackson, Isobel G
AU  - Gunter, Marc J
AU  - Botteri, Edoardo
AU  - Ferrari, Pietro
AU  - Dossus, Laure
TI  - Lifestyle changes and postmenopausal breast cancer risk in women from the European Prospective Investigation into Cancer and Nutrition.
JO  - Breast cancer research
VL  - 27
IS  - 1
SN  - 1465-5411
CY  - London
PB  - BioMed Central
M1  - DKFZ-2025-02246
SP  - 192
PY  - 2025
AB  - The risk of breast cancer has been associated with various lifestyle factors, yet the evidence regarding how lifestyle modifications affect this risk remains limited. This study examines the relationship between changes in the Healthy Lifestyle Index (HLI) and postmenopausal breast cancer risk in women participating in the European Prospective Investigation into Cancer (EPIC).HLI scores (ranging from 0 to 16) were computed based on smoking habits, alcohol consumption, body mass index (BMI), and physical activity levels, using data from baseline and follow-up questionnaires, which were separated by a median interval of 10 (IQR: 5.2-12.0) years. Among the 125,746 women included in the analyses, 2,175 developed breast cancer over a median follow-up period of nearly 4 (IQR: 2.9-8.4) years starting from the date of the second lifestyle questionnaire. Cox proportional hazards models were employed to estimate hazard ratios (HRs) and confidence intervals (CIs) for the relationship between changes in HLI and postmenopausal breast cancer risk, analysed both overall and by estrogen receptor (ER) status. Individual components of the HLI were also analysed, with sensitivity analyses addressing potential reverse causation by delaying the start of follow-up by 1 to 3 years.Each unit increase in the HLI-reflecting a healthier lifestyle-was not associated with the overall risk of postmenopausal breast cancer. Among individual components, only a one-unit increase in the BMI score, corresponding to a shift towards a healthier BMI, was inversely associated with overall (HR = 0.936; 95
KW  - Humans
KW  - Female
KW  - Breast Neoplasms: epidemiology
KW  - Breast Neoplasms: etiology
KW  - Postmenopause
KW  - Middle Aged
KW  - Europe: epidemiology
KW  - Life Style
KW  - Risk Factors
KW  - Prospective Studies
KW  - Aged
KW  - Body Mass Index
KW  - Surveys and Questionnaires
KW  - Proportional Hazards Models
KW  - Exercise
KW  - Receptors, Estrogen: metabolism
KW  - Follow-Up Studies
KW  - Breast cancer (Other)
KW  - Healthy lifestyle index (Other)
KW  - Lifestyle changes (Other)
KW  - Longitudinal (Other)
KW  - Prospective cohort (Other)
KW  - Risk (Other)
KW  - Receptors, Estrogen (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:41163053
C2  - pmc:PMC12574052
DO  - DOI:10.1186/s13058-025-02148-w
UR  - https://inrepo02.dkfz.de/record/305587
ER  -