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000305618 1001_ $$00000-0002-8713-572X$$aSchmiester, Maren$$b0
000305618 245__ $$aGenomic evolution of high-risk soft tissue sarcomas under thermo- and chemotherapeutic selection pressure.
000305618 260__ $$aLondon$$bInforma UK Limited$$c2025
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000305618 520__ $$aThe integration of regional hyperthermia into the multimodal treatment of patients with localized high-risk soft tissue sarcomas has been shown to improve overall survival. However, specific effects on the tumors' genetic makeup and biology are largely unknown. Since clonal selection of malignant cells capable of thermoresistance might contribute to disease progression, a better understanding of the induced tumor evolution could inform strategies for improving treatment efficacy.We performed whole exome sequencing on paired sarcoma samples obtained before and after treatment with chemotherapy combined with regional hyperthermia (n = 12 patients; n = 9 paired samples, n = 3 post-treatment only).Tumor evolution was evident in all paired samples, with shifts in small- and large-scale genomic alterations. Overall, these alterations appeared tumor-specific, but recurrent mutations in histone H3-modifying genes were found exclusively in post-therapeutic samples.Our findings showcase the diversity of genomic evolution patterns in sarcomas emerging under combined thermo- and chemotherapeutic selection pressure, indicating that treatment response may vary according to the specific tumor composition. With previous studies linking histone functions to heat stress response, the alterations found in genes modifying H3 in our post-therapeutic cohort provide biological evidence for synergy of chemotherapy combined with regional hyperthermia in soft tissue sarcomas.
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000305618 650_7 $$2Other$$aSoft tissue sarcoma
000305618 650_7 $$2Other$$ahistone H3.3 regulation
000305618 650_7 $$2Other$$ahyperthermia
000305618 650_7 $$2Other$$atumor evolution
000305618 650_7 $$2Other$$awhole exome sequencing
000305618 650_2 $$2MeSH$$aHumans
000305618 650_2 $$2MeSH$$aSarcoma: genetics
000305618 650_2 $$2MeSH$$aSarcoma: therapy
000305618 650_2 $$2MeSH$$aSarcoma: drug therapy
000305618 650_2 $$2MeSH$$aSarcoma: pathology
000305618 650_2 $$2MeSH$$aFemale
000305618 650_2 $$2MeSH$$aMale
000305618 650_2 $$2MeSH$$aMiddle Aged
000305618 650_2 $$2MeSH$$aHyperthermia, Induced: methods
000305618 650_2 $$2MeSH$$aAdult
000305618 650_2 $$2MeSH$$aAged
000305618 650_2 $$2MeSH$$aGenomics: methods
000305618 7001_ $$aFreytag, Antonia$$b1
000305618 7001_ $$aGillissen, Bernhard$$b2
000305618 7001_ $$aSträng, Eric$$b3
000305618 7001_ $$aHablesreiter, Raphael$$b4
000305618 7001_ $$aRichter, Antje$$b5
000305618 7001_ $$aStriefler, Jana K$$b6
000305618 7001_ $$avon Laffert, Maximilian$$b7
000305618 7001_ $$aHummel, Michael$$b8
000305618 7001_ $$aJarosch, Armin$$b9
000305618 7001_ $$aKaul, David$$b10
000305618 7001_ $$00000-0002-2747-165X$$aGhadjar, Pirus$$b11
000305618 7001_ $$aÖllinger, Robert$$b12
000305618 7001_ $$aRau, Daniel$$b13
000305618 7001_ $$aMärdian, Sven$$b14
000305618 7001_ $$0P:(DE-HGF)0$$aBullinger, Lars$$b15
000305618 7001_ $$aDolnik, Anna$$b16
000305618 7001_ $$0P:(DE-HGF)0$$aFlörcken, Anne$$b17
000305618 773__ $$0PERI:(DE-600)2907482-4$$a10.1080/02656736.2025.2573753$$gVol. 42, no. 1, p. 2573753$$n1$$p2573753$$tInternational journal of hyperthermia and thermal therapies$$v42$$x0265-6736$$y2025
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