TY  - JOUR
AU  - Bakhtiari Moghaddam, Anahita
AU  - Runz, A.
AU  - Augusto, R Figueiredo
AU  - Echner, G.
AU  - Johnen, W.
AU  - Gabriel, Richard
AU  - Haering, P.
AU  - Lang, C.
AU  - Seeber, S.
AU  - Murillo, C.
AU  - Ackermann, B.
AU  - Pestana, R.
AU  - Beyer, C.
AU  - Weykamp, F.
AU  - Jochim, M.
AU  - Qubala, A.
AU  - Batista, V.
AU  - Jäkel, O.
AU  - Karger, Christian
TI  - A dynamic anthropomorphic phantom for end-to-end testing in image- and surface-guided adaptive radiotherapy.
JO  - Medical physics
VL  - 52
IS  - 11
SN  - 0094-2405
CY  - Hoboken, NJ
PB  - Wiley
M1  - DKFZ-2025-02267
SP  - e70107
PY  - 2025
N1  - #EA:E040#LA:E040#
AB  - Respiratory and digestive motion can compromise the accuracy of radiotherapy (RT), affecting tumor targeting and healthy tissue sparing. Current phantoms often fail to replicate complex organ movements and lack compatibility with advanced imaging modalities like magnetic resonance imaging (MRI) and 4D computed tomography (4DCT), limiting their utility in adaptive radiotherapy. The BRaVIDA (Breathing Radiotherapy Visual monitoring, Imaging, and Dosimetric Anthropomorphic) phantom addresses these limitations by simulating realistic organ motion during breathing and digestion. Its MRI compatibility allows for comprehensive testing in adaptive radiotherapy workflows, improving motion management and treatment precision for both photon and ion beam therapies.This study introduces the BRaVIDA (Breathing Radiotherapy Visual monitoring, Imaging, and Dosimetric Anthropomorphic) phantom, a novel anthropomorphic phantom designed to simulate respiratory motion and support end-to-end testing in adaptive radiotherapy. The aim is to improve motion management, imaging accuracy, and dosimetric validation for radiotherapy treatments.The BRaVIDA phantom is designed with realistic anatomical structures of the thorax and abdomen and may be equipped with dosimeters. It simulates respiratory and digestive motion using an in-house developed hydraulic system. The phantom was imaged by CT and MRI, using different protocols (CT, MRI, 4DCT, and 4DMRI) to evaluate image contrast and motion parameters. Dosimetric properties were assessed by measuring the relative electron density (RED) and the stopping power ratio (SPR) of ion beams and the results were compared with the values of the treatment planning system (TPS).The phantom demonstrated realistic image contrast in CT and MRI, with anthropomorphic characteristics similar to human tissues. Motion amplitudes for various organ models (pancreas, stomach, liver) were successfully measured using 4DCT and 4DMRI. Dosimetric testing showed that the RED and SPR values of BRaVIDA align closely with TPS reference values. Deviations in photon attenuation were below 1.5
KW  - Phantoms, Imaging
KW  - Radiotherapy, Image-Guided: instrumentation
KW  - Humans
KW  - Magnetic Resonance Imaging
KW  - Respiration
KW  - Movement
KW  - Radiometry
KW  - adaptive radiotherapy (Other)
KW  - anthropomorphic phantom (Other)
KW  - end to end test (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:41185391
DO  - DOI:10.1002/mp.70107
UR  - https://inrepo02.dkfz.de/record/305619
ER  -