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@ARTICLE{Peng:305633,
      author       = {S. Peng and Q. Chen and Q. Liu and R. Xie$^*$ and Y. Wu},
      title        = {{A}ssociation of the {A}merican heart association's new
                      'life's essential 8' cardiovascular health with all-cause
                      and cardiovascular mortality in adults with and without
                      cancer: a retrospective cohort study.},
      journal      = {BMC cancer},
      volume       = {25},
      number       = {1},
      issn         = {1471-2407},
      address      = {London},
      publisher    = {BioMed Central},
      reportid     = {DKFZ-2025-02275},
      pages        = {1706},
      year         = {2025},
      abstract     = {The American Heart Association released an updated
                      algorithm used to assess cardiovascular health (CVH)-the
                      Life's Essential 8 (LE8) score. Our objective was to
                      quantify the association between CVH levels estimated by the
                      LE8 score and all-cause and cardiovascular mortality in
                      adults with and without cancer.In this retrospective cohort
                      study, 29,352 adults were included from the National Health
                      and Nutrition Examination Survey (NHANES) 2005-2018 at
                      baseline linked to the 2019 National Death Index records.
                      Cox regression models and Restricted cubic spline were used
                      to evaluate the associations between CVH with cardiovascular
                      mortality and all-cause mortality.In this study, $14.8\%$ of
                      adults achieved a high total CVH score, compared to $20.3\%$
                      with low scores. The adjusted HR $(95\%$ CI) for all-cause
                      mortality in adults without cancer with a moderate or high
                      CVH total scores compared with low scores was 0.71 (0.64,
                      0.79) and 0.46 (0.35, 0.60), respectively. The corresponding
                      adjusted HR $(95\%$ CI) for cardiovascular disease (CVD)
                      mortality was 0.58 (0.47, 0.72) and 0.30 (0.16, 0.57),
                      respectively. And all 8 CVH indicators in CVD mortality were
                      protective factors. The adjusted HRs $(95\%$ CI) for
                      all-cause mortality in adults with cancer with moderate or
                      high scores were 0.73 (0.58, 0.92) and 0.75 (0.48, 1.18),
                      respectively.According to the new LE8, higher CVH scores
                      were associated with a reduced risk of all-cause and
                      CVD-specific mortality in adults with and without cancer.},
      keywords     = {Humans / Cardiovascular Diseases: mortality / Neoplasms:
                      mortality / Neoplasms: complications / Neoplasms:
                      epidemiology / Female / Male / Retrospective Studies /
                      Middle Aged / Adult / American Heart Association / Nutrition
                      Surveys / United States: epidemiology / Aged / Cause of
                      Death / Cancer (Other) / Cardiovascular health (Other) /
                      Life's essential 8 (Other) / Mortality (Other)},
      cin          = {C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41188772},
      doi          = {10.1186/s12885-025-14464-7},
      url          = {https://inrepo02.dkfz.de/record/305633},
}