%0 Journal Article
%A His, Mathilde
%A Fournier, Agnès
%A Truong, Thérèse
%A Gelot, Amandine
%A Navionis, Anne-Sophie
%A Biessy, Carine
%A Ferrari, Pietro
%A Tjønneland, Anne
%A Kaaks, Rudolf
%A Fortner, Renée T
%A Schulze, Matthias B
%A Masala, Giovanna
%A Sieri, Sabina
%A Tumino, Rosario
%A Catalano, Alberto
%A Gram, Inger T
%A Olsen, Karina Standahl
%A Castro-Espin, Carlota
%A Guevara, Marcela
%A Aizpurua Atxega, Amaia
%A Chilarque, María-Dolores
%A Tin Tin, Sandar
%A Heath, Alicia
%A Christakoudi, Sofia
%A Aglago, Elom Kouassivi
%A Gunter, Marc J
%A Rinaldi, Sabina
%T Prospective evaluation of circulating plasma thyroid hormones concentrations and breast cancer risk in the EPIC cohort.
%J EBioMedicine
%V 121
%@ 2352-3964
%C Amsterdam [u.a.]
%I Elsevier
%M DKFZ-2025-02278
%P 106011
%D 2025
%X Hyperthyroidism has been associated with increased risk of breast cancer and in vitro studies have shown that thyroid hormones may influence breast tumorigenesis. We aimed to study associations between prediagnostic circulating thyroid hormone concentrations and breast cancer risk.We evaluated associations between breast cancer risk and circulating concentrations of thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4), fT3/fT4 ratio, and anti-thyroid peroxidase antibody (TPO-Ab) positivity, in plasma samples from 1518 invasive breast cancer cases (diagnosed between 2 and 14 years after blood collection) and 1518 matched controls from a case-control study nested in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort using validated immunoassays. Conditional logistic regression models were used to evaluate associations with breast cancer, with adjustment for established breast cancer risk factors.In fully adjusted models, fT3 (ORper standard deviation (SD) (95
%K Breast cancer (Other)
%K Prospective study (Other)
%K Thyroid hormones (Other)
%K Thyroid-stimulating hormone (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41187615
%R 10.1016/j.ebiom.2025.106011
%U https://inrepo02.dkfz.de/record/305636