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@ARTICLE{Huang:305649,
      author       = {Q. Huang and Y. Cheng and R. Lei and Z. Chen and W. Gu and
                      K. Hemminki$^*$ and T. Chen},
      title        = {{G}lobal burden of lung cancer attributable to occupational
                      asbestos exposure: 1990 to 2021.},
      journal      = {Environmental health},
      volume       = {24},
      number       = {1},
      issn         = {1476-069X},
      address      = {London},
      publisher    = {BioMed Central},
      reportid     = {DKFZ-2025-02281},
      pages        = {84},
      year         = {2025},
      note         = {C020?},
      abstract     = {Asbestos is a well-established occupational carcinogen,
                      with strong evidence linking its exposure to lung cancer.
                      Despite increasing awareness of its health risks, asbestos
                      continues to be used in many countries. We aimed to evaluate
                      the global burden of lung cancer attributable to
                      occupational asbestos exposure and to analyze its
                      epidemiological patterns across time and by regions, sex,
                      and age.We utilized lung cancer data from the Global Burden
                      of Disease (GBD) 2021 database, including information on new
                      cases, deaths, and disability-adjusted life-years (DALYs),
                      along with their age-standardized rates by gender and age
                      groups. Temporal trends were examined using Joinpoint
                      regression models with $95\%$ confidence intervals (CIs).
                      The timeline data on global asbestos bans were retrieved
                      from the International Ban Asbestos Secretariat.We observed,
                      approximately 25 years after the complete ban on asbestos
                      use, a declining trend for lung cancer incidence, as well as
                      for mortality and DALYs due to asbestos exposure. In 2021,
                      occupational asbestos exposure accounted for $9.4\%$ of
                      global lung cancer deaths and $7.2\%$ of DALYs. Between 1990
                      and 2021, the number of asbestos-related lung cancer deaths
                      increased from 0.13 million to 0.19 million, while DALYs
                      rose from 2.58 million to 3.34 million. The highest deaths
                      and DALYs were observed in regions with high
                      Socio-demographic Index (SDI), though the most rapid
                      increases occurred in lower SDI regions. Over time, lung
                      cancer burden shifted towards older populations, especially
                      those aged over 70.We found, for the first time, that a
                      complete ban on asbestos with a lag time of 25 years could
                      effectively reduce lung cancer incidence along with
                      asbestos-related deaths and DALYs. These findings underscore
                      the urgent need for a complete ban on asbestos (especially
                      chrysotile).},
      keywords     = {Humans / Lung Neoplasms: epidemiology / Lung Neoplasms:
                      chemically induced / Lung Neoplasms: mortality /
                      Occupational Exposure: adverse effects / Asbestos: adverse
                      effects / Asbestos: toxicity / Male / Female / Middle Aged /
                      Aged / Adult / Global Burden of Disease: trends / Incidence
                      / Global Health: statistics $\&$ numerical data / Young
                      Adult / Aged, 80 and over / Disability-Adjusted Life Years /
                      Occupational Diseases: epidemiology / Adolescent / Asbestos
                      ban (Other) / Chrysotile (Other) / Global Burden of Disease
                      (GBD) 2021 (Other) / Lung cancer (Other) / Occupational
                      asbestos exposure (Other) / Asbestos (NLM Chemicals)},
      cin          = {Z999 / C020},
      ddc          = {610},
      cid          = {I:(DE-He78)Z999-20160331 / I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41168773},
      pmc          = {pmc:PMC12573932},
      doi          = {10.1186/s12940-025-01217-z},
      url          = {https://inrepo02.dkfz.de/record/305649},
}