%0 Journal Article
%A Duff, Ashley J
%A Junkins, Anna
%A Chen, Li
%A Mannion, Kyle
%A Topf, Michael C
%A Waterboer, Tim
%A Michels, Birgitta E
%A Butt, Julia
%A Woodward, Beverly O
%A Lima, Morgan C
%A Erdem, Husamettin
%A Leonard, Michael A
%A Turner, Megan M
%A Sudenga, Staci L
%A Lang Kuhs, Krystle A
%T The association between human papillomavirus type 16 seropositivity and oropharyngeal cancer among men living with HIV.
%J Cancer
%V 131
%N 22
%@ 0008-543X
%C New York, NY
%I Wiley-Liss
%M DKFZ-2025-02290
%P e70167
%D 2025
%Z ISSN 1097-0142
%X There are no methods for the early detection of human papillomavirus-driven oropharyngeal squamous cell carcinoma (HPV+OPSCC); however, HPV16 E6 seropositivity has been identified as a promising screening marker. Although people living with HIV have a higher risk of developing HPV+OPSCC, few studies have evaluated the association between HPV16 antibodies and HPV+OPSCC.The association between HPV16 seropositivity (L1, E1, E2, E4, E6, and E7) and OPSCC was assessed among 2331 men living with HIV (MLWH) aged ≥40 years who had blood specimens banked within the Tennessee Center for AIDS Research biorepository between 2001 and 2019; some samples were collected before OPSCC diagnosis, and others after. The association between HPV16 seropositivity and OPSCC was analyzed via univariable logistic regression.One hundred and thirty-five HPV16 E6 seropositive cases and 11 OPSCC cases were identified. HPV16 E6 seropositivity was associated with a 14-fold higher odds of OPSCC (odds ratio [OR], 14.04; 95
%K Humans
%K Male
%K Oropharyngeal Neoplasms: virology
%K Oropharyngeal Neoplasms: blood
%K Oropharyngeal Neoplasms: epidemiology
%K Oropharyngeal Neoplasms: diagnosis
%K Oropharyngeal Neoplasms: immunology
%K Middle Aged
%K Human papillomavirus 16: immunology
%K Human papillomavirus 16: isolation & purification
%K Papillomavirus Infections: virology
%K Papillomavirus Infections: complications
%K Papillomavirus Infections: immunology
%K Papillomavirus Infections: epidemiology
%K Papillomavirus Infections: blood
%K HIV Infections: complications
%K HIV Infections: virology
%K HIV Infections: immunology
%K Adult
%K Oncogene Proteins, Viral: immunology
%K Antibodies, Viral: blood
%K Aged
%K Repressor Proteins: immunology
%K HPV (Other)
%K HPV16 E6 antibodies (Other)
%K human papillomavirus (Other)
%K oropharyngeal cancer (Other)
%K serology (Other)
%K Oncogene Proteins, Viral (NLM Chemicals)
%K Antibodies, Viral (NLM Chemicals)
%K E6 protein, Human papillomavirus type 16 (NLM Chemicals)
%K Repressor Proteins (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41199491
%R 10.1002/cncr.70167
%U https://inrepo02.dkfz.de/record/305660