TY  - JOUR
AU  - Duff, Ashley J
AU  - Junkins, Anna
AU  - Chen, Li
AU  - Mannion, Kyle
AU  - Topf, Michael C
AU  - Waterboer, Tim
AU  - Michels, Birgitta E
AU  - Butt, Julia
AU  - Woodward, Beverly O
AU  - Lima, Morgan C
AU  - Erdem, Husamettin
AU  - Leonard, Michael A
AU  - Turner, Megan M
AU  - Sudenga, Staci L
AU  - Lang Kuhs, Krystle A
TI  - The association between human papillomavirus type 16 seropositivity and oropharyngeal cancer among men living with HIV.
JO  - Cancer
VL  - 131
IS  - 22
SN  - 0008-543X
CY  - New York, NY
PB  - Wiley-Liss
M1  - DKFZ-2025-02290
SP  - e70167
PY  - 2025
N1  - ISSN 1097-0142
AB  - There are no methods for the early detection of human papillomavirus-driven oropharyngeal squamous cell carcinoma (HPV+OPSCC); however, HPV16 E6 seropositivity has been identified as a promising screening marker. Although people living with HIV have a higher risk of developing HPV+OPSCC, few studies have evaluated the association between HPV16 antibodies and HPV+OPSCC.The association between HPV16 seropositivity (L1, E1, E2, E4, E6, and E7) and OPSCC was assessed among 2331 men living with HIV (MLWH) aged ≥40 years who had blood specimens banked within the Tennessee Center for AIDS Research biorepository between 2001 and 2019; some samples were collected before OPSCC diagnosis, and others after. The association between HPV16 seropositivity and OPSCC was analyzed via univariable logistic regression.One hundred and thirty-five HPV16 E6 seropositive cases and 11 OPSCC cases were identified. HPV16 E6 seropositivity was associated with a 14-fold higher odds of OPSCC (odds ratio [OR], 14.04; 95
KW  - Humans
KW  - Male
KW  - Oropharyngeal Neoplasms: virology
KW  - Oropharyngeal Neoplasms: blood
KW  - Oropharyngeal Neoplasms: epidemiology
KW  - Oropharyngeal Neoplasms: diagnosis
KW  - Oropharyngeal Neoplasms: immunology
KW  - Middle Aged
KW  - Human papillomavirus 16: immunology
KW  - Human papillomavirus 16: isolation & purification
KW  - Papillomavirus Infections: virology
KW  - Papillomavirus Infections: complications
KW  - Papillomavirus Infections: immunology
KW  - Papillomavirus Infections: epidemiology
KW  - Papillomavirus Infections: blood
KW  - HIV Infections: complications
KW  - HIV Infections: virology
KW  - HIV Infections: immunology
KW  - Adult
KW  - Oncogene Proteins, Viral: immunology
KW  - Antibodies, Viral: blood
KW  - Aged
KW  - Repressor Proteins: immunology
KW  - HPV (Other)
KW  - HPV16 E6 antibodies (Other)
KW  - human papillomavirus (Other)
KW  - oropharyngeal cancer (Other)
KW  - serology (Other)
KW  - Oncogene Proteins, Viral (NLM Chemicals)
KW  - Antibodies, Viral (NLM Chemicals)
KW  - E6 protein, Human papillomavirus type 16 (NLM Chemicals)
KW  - Repressor Proteins (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:41199491
DO  - DOI:10.1002/cncr.70167
UR  - https://inrepo02.dkfz.de/record/305660
ER  -