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000305668 1001_ $$00009-0003-2146-2650$$aFranchi, Sara$$b0
000305668 245__ $$aHeavy Alkaline Earth Radiometals for Cancer Theranostics: Coordination and Radiochemistry of Radium-223 and Barium-131 with Kryptofix 22-Based Chelators.
000305668 260__ $$aWashington, DC$$bAmerican Chemical Society$$c2025
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000305668 500__ $$a2025 Nov 17;64(45):22422-22440
000305668 520__ $$aThe possibility of pairing the α-emitter 223Ra for targeted α therapy with the γ-emitter 131Ba for SPECT imaging could unlock novel theranostic options in cancer management. However, the lack of stable in vivo chelation for Ra2+/Ba2+ remains a key barrier to clinical use. Four macrocyclic chelators were herein developed by functionalizing 1,10-diaza-18-crown-6 (Kryptofix 22) with donor groups tailored to Ra2+/Ba2+: 2-pyridylphosphonic acid (macrophospho), malonic acid (macromal), catechol (macrocat), and 1,2-HOPO (macroHOPO). The thermodynamic and structural properties of their Ba2+ and Ra2+ complexes were explored in aqueous solution through potentiometry, NMR spectroscopy, X-ray crystallography and DFT calculations. Macromal gave the highest stability constant known so far for a 1:1 Ba2+-to-ligand fully deprotonated complex (logβ = 16.6), even higher than that of Ba2+-macropa, the current state-of-the-art chelator for 223Ra/131Ba. The experimental complex stability followed the order macromal > macropa ≫ macrophospho ∼ macroHOPO > macrocat. Concentration-, temperature-, pH-, and time-dependent radiolabeling were carried out using 223Ra derived from Xofigo residues and cyclotron-produced 131Ba. Although quantitative 223Ra/131Ba incorporation was not achieved, this work expands the scarce coordination chemistry and radiochemistry of the two heaviest alkaline earth (radio)metals.
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000305668 7001_ $$aAsti, Mattia$$b1
000305668 7001_ $$00009-0009-1358-3560$$aBlei, Magdalena K$$b2
000305668 7001_ $$aPozzo, Silvia$$b3
000305668 7001_ $$aMadabeni, Andrea$$b4
000305668 7001_ $$00000-0002-9908-6961$$aGraiff, Claudia$$b5
000305668 7001_ $$aMenegazzo, Ileana$$b6
000305668 7001_ $$aVolpato, Francesca$$b7
000305668 7001_ $$aGentile, Silvia$$b8
000305668 7001_ $$00000-0002-1673-5111$$aOrian, Laura$$b9
000305668 7001_ $$00000-0003-0786-0364$$aMancin, Fabrizio$$b10
000305668 7001_ $$aStadlbauer, Sven$$b11
000305668 7001_ $$0P:(DE-He78)9793347ba83f527b81a22ab75af9378a$$aKopka, Klaus$$b12
000305668 7001_ $$00000-0003-1906-3186$$aMamat, Constantin$$b13
000305668 7001_ $$00000-0001-6108-746X$$aDi Marco, Valerio$$b14
000305668 7001_ $$00000-0002-3726-6174$$aTosato, Marianna$$b15
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