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@ARTICLE{Michaud:305670,
      author       = {D. S. Michaud and E. A. Platz and W. S. Garrett and T.
                      Waterboer$^*$ and R. Kaaks$^*$ and F. Pasanisi and E.
                      Abilleira and V. Pala and L. Milani and J. Castilla and D.
                      Rodriguez Palacios and R. Tumino and G. Masala and M.
                      Farràs and M.-J. Sánchez and K. Papier and G. Severi and
                      K. K. Tsilidis and M. Jenab and J. A. Butt$^*$ and D. J.
                      Hughes},
      title        = {{A}ntibody responses to 11 {F}usobacterium proteins and
                      colorectal cancer-specific and overall survival in the
                      {EPIC} cohort.},
      journal      = {Cancer epidemiology, biomarkers $\&$ prevention},
      volume       = {nn},
      issn         = {1055-9965},
      address      = {Philadelphia, Pa.},
      publisher    = {AACR},
      reportid     = {DKFZ-2025-02300},
      pages        = {nn},
      year         = {2025},
      note         = {epub},
      abstract     = {While there is evidence that Fusobacterium spp. in colon
                      tissue is associated with prognosis, less is known about the
                      association between antibody response to antigens expressed
                      by fusobacteria and colorectal cancer (CRC)-specific
                      mortality.Antibody responses to 11 Fusobacterium nucleatum
                      (ATCC 25586) antigens were measured in pre-diagnostic blood
                      for 471 incident CRC cases (median time to diagnosis=3.4
                      years), among whom 188 CRC-specific deaths and 250 total
                      deaths were confirmed over a median follow-up of 9.2 years
                      in the European Prospective Investigation into Cancer and
                      Nutrition (EPIC) cohort. Cox models were conducted to
                      examine associations between antigen seropositivity and
                      CRC-specific mortality.Seropositivity to fusobacterial
                      antigens was not associated with overall or CRC-specific
                      mortality, individually or combined. Similar results were
                      observed when restricting to patients who donated blood <3
                      years prior to cancer diagnosis. When restricting to
                      individuals diagnosed at an earlier age of onset (<55 years;
                      N=74), we observed positive associations for seropositivity
                      to three fusobacteria antigens reflecting different putative
                      autotransporter adhesins. The strongest association was for
                      Fn1893 antigen seropositivity (HR: 6.95, $95\%$ CI:
                      1.78-27.2, compared to none) and CRC-specific mortality, but
                      confidence intervals were wide.While null overall, this is
                      the first study to observe an association between antibody
                      response to fusobacteria and CRC-specific mortality among
                      individuals with earlier onset CRC. Future studies are
                      needed to confirm these findings and understand the role of
                      systemic antibody responses to fusobacteria in
                      cancer.Specific antigens expressed by fusobacteria may play
                      a role in mortality from earlier onset CRCs.},
      cin          = {D320 / C020},
      ddc          = {610},
      cid          = {I:(DE-He78)D320-20160331 / I:(DE-He78)C020-20160331},
      pnm          = {319H - Addenda (POF4-319H)},
      pid          = {G:(DE-HGF)POF4-319H},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41196234},
      doi          = {10.1158/1055-9965.EPI-25-1084},
      url          = {https://inrepo02.dkfz.de/record/305670},
}