TY  - JOUR
AU  - Hertel, Alexander
AU  - Streuer, Alexander
AU  - Diehl, Steffen
AU  - Boch, Tobias
AU  - Nörenberg, Dominik
AU  - Strittmatter, Anika
AU  - Zöllner, Frank G
AU  - Schoenberg, Stefan O
AU  - Hofmann, Wolf-Karsten
AU  - Loges, Sonja
AU  - Nowak, Daniel
AU  - Froelich, Matthias F
TI  - Targeting tumoral heterogeneity in lung cancer: a novel, CT-texture-guided targeted biopsy approach with exome sequencing.
JO  - npj precision oncology
VL  - 9
IS  - 1
SN  - 2397-768X
CY  - [London]
PB  - Springer Nature
M1  - DKFZ-2025-02308
SP  - 342
PY  - 2025
AB  - Solid tumors like lung cancer show significant mutational heterogeneity. A biopsy captures only focal aspects, limiting conclusions about overall tumor biology. This prospective study correlated CT-based radiomics features with genomic profiles to optimize biopsy site selection. Lung cancer patients underwent CT imaging, radiomics analysis, targeted biopsies, and whole-exome sequencing. Twelve non-redundant features were extracted, with JointEntropy guiding biopsy targeting. In 7 of 12 patients, over 10
LB  - PUB:(DE-HGF)16
C6  - pmid:41203783
C2  - pmc:PMC12594912
DO  - DOI:10.1038/s41698-025-01148-5
UR  - https://inrepo02.dkfz.de/record/305685
ER  -