%0 Journal Article
%A Estrella, Michelle M
%A Ballew, Shoshana H
%A Sang, Yingying
%A Grams, Morgan E
%A Coresh, Josef
%A Surapaneni, Aditya
%A Alencar de Pinho, Natalia
%A Ärnlöv, Johan
%A Brenner, Hermann
%A Carrero, Juan-Jesus
%A Chen, Teresa K
%A Cohen, Debbie L
%A Cushman, Mary
%A Gansevoort, Ron T
%A Hwang, Shih-Jen
%A Inker, Lesley A
%A Ix, Joachim H
%A Kabasawa, Keiko
%A Konta, Tsuneo
%A Lees, Jennifer S
%A Polkinghorne, Kevan R
%A Shlipak, Michael G
%A Vernooij, Robin W M
%A Wheeler, David C
%A Yadav, Ashok Kumar
%A Levey, Andrew S
%A Eckardt, Kai-Uwe
%A Investigators, Chronic Kidney Disease Prognosis Consortium
%T Discordance in Creatinine- and Cystatin C-Based eGFR and Clinical Outcomes: A Meta-Analysis.
%J The journal of the American Medical Association
%V 334
%N 21
%@ 0254-9077
%C Chicago, Ill.
%I American Medical Association
%M DKFZ-2025-02334
%P 1915-1926
%D 2025
%Z 2025 Dec 2;334(21):1915-1926
%X Estimated glomerular filtration rates (eGFRs) can differ according to whether creatinine or cystatin C is used for the eGFR calculation, but the prevalence and importance of these differences remain unclear.To evaluate the prevalence of a discordance between cystatin C-based eGFR (eGFRcys) and creatinine-based eGFR (eGFRcr), identify characteristics associated with greater discordance, and evaluate associations of discordance with adverse outcomes.Participants in the Chronic Kidney Disease Prognosis Consortium (CKD-PC).Participants with concurrent cystatin C and creatinine measurements and clinical outcome measurement.Between April 2024 and August 2025, data were synthesized using individual-level meta-analysis.The primary independent measurement was a large negative eGFR difference (eGFRdiff), defined as an eGFRcys that was at least 30
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41202182
%2 pmc:PMC12595547
%R 10.1001/jama.2025.17578
%U https://inrepo02.dkfz.de/record/305711