TY  - JOUR
AU  - Estrella, Michelle M
AU  - Ballew, Shoshana H
AU  - Sang, Yingying
AU  - Grams, Morgan E
AU  - Coresh, Josef
AU  - Surapaneni, Aditya
AU  - Alencar de Pinho, Natalia
AU  - Ärnlöv, Johan
AU  - Brenner, Hermann
AU  - Carrero, Juan-Jesus
AU  - Chen, Teresa K
AU  - Cohen, Debbie L
AU  - Cushman, Mary
AU  - Gansevoort, Ron T
AU  - Hwang, Shih-Jen
AU  - Inker, Lesley A
AU  - Ix, Joachim H
AU  - Kabasawa, Keiko
AU  - Konta, Tsuneo
AU  - Lees, Jennifer S
AU  - Polkinghorne, Kevan R
AU  - Shlipak, Michael G
AU  - Vernooij, Robin W M
AU  - Wheeler, David C
AU  - Yadav, Ashok Kumar
AU  - Levey, Andrew S
AU  - Eckardt, Kai-Uwe
AU  - Investigators, Chronic Kidney Disease Prognosis Consortium
TI  - Discordance in Creatinine- and Cystatin C-Based eGFR and Clinical Outcomes: A Meta-Analysis.
JO  - The journal of the American Medical Association
VL  - 334
IS  - 21
SN  - 0254-9077
CY  - Chicago, Ill.
PB  - American Medical Association
M1  - DKFZ-2025-02334
SP  - 1915-1926
PY  - 2025
N1  - 2025 Dec 2;334(21):1915-1926
AB  - Estimated glomerular filtration rates (eGFRs) can differ according to whether creatinine or cystatin C is used for the eGFR calculation, but the prevalence and importance of these differences remain unclear.To evaluate the prevalence of a discordance between cystatin C-based eGFR (eGFRcys) and creatinine-based eGFR (eGFRcr), identify characteristics associated with greater discordance, and evaluate associations of discordance with adverse outcomes.Participants in the Chronic Kidney Disease Prognosis Consortium (CKD-PC).Participants with concurrent cystatin C and creatinine measurements and clinical outcome measurement.Between April 2024 and August 2025, data were synthesized using individual-level meta-analysis.The primary independent measurement was a large negative eGFR difference (eGFRdiff), defined as an eGFRcys that was at least 30
LB  - PUB:(DE-HGF)16
C6  - pmid:41202182
C2  - pmc:PMC12595547
DO  - DOI:10.1001/jama.2025.17578
UR  - https://inrepo02.dkfz.de/record/305711
ER  -