%0 Journal Article
%A Seiler, Isabell
%A Schäfer, Sebastian
%A von Wachter, Camilla
%A Balermpas, Panagiotis
%A Slavik, Marek
%A Burkon, Petr
%A Meents, Johannes
%A Kästner, Lena
%A Lohaus, Fabian
%A Willner, Jochen
%A Schunn, Anna Sabrina
%A Drabke, Sophia
%A Klischies, Kenneth
%A Wittenstein, Olaf
%A Bank, Priska
%A Partl, Richard
%A Müller, Jörg-Andreas
%A Gawish, Ahmed
%A Grün, Arne
%A Baehr, Andrea
%A Trommer, Maike
%A Glasmacher, Andrea
%A Mader, Thomas
%A Holy, Richard
%A Dzierma, Yvonne
%A Ehret, Felix
%A Rühle, Alexander
%A Guckenberger, Matthias
%A Moustakis, Christos
%A Brunner, Thomas
%A Blanck, Oliver
%A Boda-Heggemann, Judit
%A Nicolay, Nils H
%A Nägler, Franziska
%T Impact of target volume and dose concepts on the outcomes of prostate cancer patients treated with stereotactic body radiotherapy for spinal metastases - a European multicenter cohort study.
%J Radiotherapy and oncology
%V 214
%@ 0167-8140
%C Amsterdam [u.a.]
%I Elsevier Science
%M DKFZ-2025-02363
%P 111276
%D 2026
%Z Volume 214, January 2026, 111276
%X The importance of metastasis-directed radiotherapy is increasing in the management of oligometastatic prostate cancer. We evaluated different target volume and dose concepts for stereotactic body radiotherapy (SBRT) of spine bone metastases (BoM) from prostate cancer in a large European cohort.Data of prostate cancer patients receiving SBRT for spine BoM between 2010 and 2024 at 19 European cancer centers were retrospectively collected. Treatment volumes and dose concepts were analyzed regarding their impact on overall survival (OS), freedom from local recurrence (FFLR), biochemical recurrence-free survival (BRFS), and progression-free survival (PFS).With a median follow-up of 25.1 months (range: 1.4-77.2), 213 patients with 283 spine BoM were evaluated. 1-/3-year PFS with simultaneously integrated boost (SIB) were 85.7 
%K Bone metastases (Other)
%K Dose concept (Other)
%K Metastasis-Directed therapy (MDT) (Other)
%K Prostate cancer (Other)
%K Spine metastases (Other)
%K Stereotactic radiotherapy (Other)
%K Target concept (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41213475
%R 10.1016/j.radonc.2025.111276
%U https://inrepo02.dkfz.de/record/305740