TY  - JOUR
AU  - Seiler, Isabell
AU  - Schäfer, Sebastian
AU  - von Wachter, Camilla
AU  - Balermpas, Panagiotis
AU  - Slavik, Marek
AU  - Burkon, Petr
AU  - Meents, Johannes
AU  - Kästner, Lena
AU  - Lohaus, Fabian
AU  - Willner, Jochen
AU  - Schunn, Anna Sabrina
AU  - Drabke, Sophia
AU  - Klischies, Kenneth
AU  - Wittenstein, Olaf
AU  - Bank, Priska
AU  - Partl, Richard
AU  - Müller, Jörg-Andreas
AU  - Gawish, Ahmed
AU  - Grün, Arne
AU  - Baehr, Andrea
AU  - Trommer, Maike
AU  - Glasmacher, Andrea
AU  - Mader, Thomas
AU  - Holy, Richard
AU  - Dzierma, Yvonne
AU  - Ehret, Felix
AU  - Rühle, Alexander
AU  - Guckenberger, Matthias
AU  - Moustakis, Christos
AU  - Brunner, Thomas
AU  - Blanck, Oliver
AU  - Boda-Heggemann, Judit
AU  - Nicolay, Nils H
AU  - Nägler, Franziska
TI  - Impact of target volume and dose concepts on the outcomes of prostate cancer patients treated with stereotactic body radiotherapy for spinal metastases - a European multicenter cohort study.
JO  - Radiotherapy and oncology
VL  - 214
SN  - 0167-8140
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DKFZ-2025-02363
SP  - 111276
PY  - 2026
N1  - Volume 214, January 2026, 111276
AB  - The importance of metastasis-directed radiotherapy is increasing in the management of oligometastatic prostate cancer. We evaluated different target volume and dose concepts for stereotactic body radiotherapy (SBRT) of spine bone metastases (BoM) from prostate cancer in a large European cohort.Data of prostate cancer patients receiving SBRT for spine BoM between 2010 and 2024 at 19 European cancer centers were retrospectively collected. Treatment volumes and dose concepts were analyzed regarding their impact on overall survival (OS), freedom from local recurrence (FFLR), biochemical recurrence-free survival (BRFS), and progression-free survival (PFS).With a median follow-up of 25.1 months (range: 1.4-77.2), 213 patients with 283 spine BoM were evaluated. 1-/3-year PFS with simultaneously integrated boost (SIB) were 85.7 
KW  - Bone metastases (Other)
KW  - Dose concept (Other)
KW  - Metastasis-Directed therapy (MDT) (Other)
KW  - Prostate cancer (Other)
KW  - Spine metastases (Other)
KW  - Stereotactic radiotherapy (Other)
KW  - Target concept (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:41213475
DO  - DOI:10.1016/j.radonc.2025.111276
UR  - https://inrepo02.dkfz.de/record/305740
ER  -