%0 Journal Article
%A Cantré, Daniel
%A Gemescu, Ioan
%A Gerigk, Lars
%A Nagel, Armin M
%A Essig, Marco
%A Langner, Sönke
%A Weber, Marc-Andre
%T Added value of sodium MRI in multiparametric MRI for WHO grade II astrocytoma surveillance during "watchful waiting": initial experience.   [Zusätzlicher Nutzen der Natrium-MRT bei multiparametrischer MRT zur Überwachung von WHO Grad II Astrozytomen während beobachtenden Abwartens: erste Erfahrungen]
%J Die Radiologie
%V 65
%N Suppl. 1
%@ 2731-7048
%C [Berlin]
%I Springer Medizin Verlag GmbH
%M DKFZ-2025-02418
%P 126-132
%D 2025
%Z #LA:E040# / 2025 Nov;65(Suppl 1):126-132
%X Unresectable WHO grade II astrocytomas require continuous imaging surveillance. To evaluate whether sodium MRI (23Na-MRI) adds diagnostic value to multiparametric MRI and helps predict progressive disease (PD), patients monitored under a 'watchful waiting' strategy were repeatedly examined.Overall, 18 patients with biopsy-proven WHO grade II astrocytoma (10 female, mean age 42 ± 15 years) were prospectively included after baseline imaging. The imaging protocol comprised morphological MRI (T2 TSE, T2 FLAIR, pre- and post-contrast T1 SE), DSC perfusion MRI (n = 17), and 23Na-MRI (n = 9) at 3 T. At baseline, evaluable 23Na-MRI was available for six patients. The Response Assessment in Neuro-Oncology criteria were used to define PD. Semiquantitative ROI analysis was performed on DSC- and 23Na-MRI. Data were analyzed using the Cox regression model.In 14 patients (78
%K 3D radial gradient echo projection imaging sequence (Other)
%K Brain tumor (Other)
%K DSC perfusion MRI (Other)
%K Low grade astrocytoma (Other)
%K MRI in oncology (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41222668
%R 10.1007/s00117-025-01531-0
%U https://inrepo02.dkfz.de/record/306178