TY  - JOUR
AU  - Cantré, Daniel
AU  - Gemescu, Ioan
AU  - Gerigk, Lars
AU  - Nagel, Armin M
AU  - Essig, Marco
AU  - Langner, Sönke
AU  - Weber, Marc-Andre
TI  - Added value of sodium MRI in multiparametric MRI for WHO grade II astrocytoma surveillance during "watchful waiting": initial experience.   [Zusätzlicher Nutzen der Natrium-MRT bei multiparametrischer MRT zur Überwachung von WHO Grad II Astrozytomen während beobachtenden Abwartens: erste Erfahrungen]
JO  - Die Radiologie
VL  - 65
IS  - Suppl. 1
SN  - 2731-7048
CY  - [Berlin]
PB  - Springer Medizin Verlag GmbH
M1  - DKFZ-2025-02418
SP  - 126-132
PY  - 2025
N1  - #LA:E040# / 2025 Nov;65(Suppl 1):126-132
AB  - Unresectable WHO grade II astrocytomas require continuous imaging surveillance. To evaluate whether sodium MRI (23Na-MRI) adds diagnostic value to multiparametric MRI and helps predict progressive disease (PD), patients monitored under a 'watchful waiting' strategy were repeatedly examined.Overall, 18 patients with biopsy-proven WHO grade II astrocytoma (10 female, mean age 42 ± 15 years) were prospectively included after baseline imaging. The imaging protocol comprised morphological MRI (T2 TSE, T2 FLAIR, pre- and post-contrast T1 SE), DSC perfusion MRI (n = 17), and 23Na-MRI (n = 9) at 3 T. At baseline, evaluable 23Na-MRI was available for six patients. The Response Assessment in Neuro-Oncology criteria were used to define PD. Semiquantitative ROI analysis was performed on DSC- and 23Na-MRI. Data were analyzed using the Cox regression model.In 14 patients (78
KW  - 3D radial gradient echo projection imaging sequence (Other)
KW  - Brain tumor (Other)
KW  - DSC perfusion MRI (Other)
KW  - Low grade astrocytoma (Other)
KW  - MRI in oncology (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:41222668
DO  - DOI:10.1007/s00117-025-01531-0
UR  - https://inrepo02.dkfz.de/record/306178
ER  -