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@ARTICLE{Hoffmann:306257,
      author       = {C. Hoffmann$^*$ and H. Hautzel$^*$ and M. Wiesweg$^*$ and
                      D. Kersting$^*$ and N. Guberina$^*$ and C. Pöttgen$^*$ and
                      M. Metzenmacher$^*$ and M. Schuler$^*$ and T. Gauler$^*$ and
                      B. Höing$^*$ and C. Kürten$^*$ and F. Doerr$^*$ and S.
                      Bölükbas$^*$ and N. Baldes$^*$ and M. Opitz$^*$ and A.
                      Milosevic$^*$ and F. Nensa$^*$ and L. Umutlu$^*$ and F.
                      Funke$^*$ and W. P. Fendler$^*$ and K. Herrmann$^*$ and M.
                      Stuschke$^*$ and M. Guberina$^*$},
      title        = {[18{F}]{FDG}-{PET}/{CT}-based evaluation of tumor response
                      kinetics during induction chemotherapy and concurrent
                      radiochemotherapy in stage {II} - {III} small-cell lung
                      cancer.},
      journal      = {European journal of nuclear medicine and molecular imaging},
      volume       = {nn},
      issn         = {1619-7070},
      address      = {Heidelberg [u.a.]},
      publisher    = {Springer-Verl.},
      reportid     = {DKFZ-2025-02486},
      pages        = {nn},
      year         = {2025},
      note         = {epub},
      abstract     = {Evaluation of interim-[18F]FDG-PET/CT as a prognostic tool
                      in limited disease small cell lung cancer (SCLC).We included
                      35 patients with limited disease SCLC from a prospective
                      institutional registry in this retrospective study. Patients
                      received induction chemotherapy (3-4 cycles) followed by
                      concurrent radiochemotherapy. Baseline [18F]FDG-PET/CT was
                      performed before or shortly after start of induction
                      chemotherapy, interim PET/CT was acquired during late
                      induction or concurrent chemoradiotherapy. Maximum
                      standardized uptake value (SUVmax), metabolic target volume
                      (MTV), and total lesion glycolysis values (TLG) were
                      determined. An exponential decay model with an asymptotic
                      offset was used to describe treatment response over time.
                      Deviations > 2 standard deviations (SD) above
                      model-predicted means after day 30 were considered poor
                      response. Progression-free survival (PFS) was analyzed.All
                      patients underwent twice-daily radiotherapy to a base dose
                      of 45 Gy. SUVmax showed greater inter-patient variability
                      than MTV. Poor treatment response was observed in $17\%,$
                      $31\%,$ or $14\%$ at the SUVmax, MTV and TLG endpoints.
                      Deviations > 2 SD from the model in SUVmax and TLG were
                      significantly associated with shorter PFS (p = 0.0003, p =
                      0.0014); MTV was not prognostic (p = 0.2630). Leave-one-out
                      cross-validation (LOOCV) could confirm the prognostic value
                      of the standardized residual SUVmax larger than 2 standard
                      deviations above model estimate as negative PFS predictor (p
                      = 0.0152, Fishers exact test).Our decay model enables the
                      characterization of [18F]FDG-PET/CT response parameters from
                      scans acquired at variable time points during induction
                      chemotherapy and at start of concurrent radiochemotherapy.
                      Poor SUVmax or TLG response was predictive of PFS.
                      Interim-[18F]FDG-PET/CT response may guide individualized
                      treatment adaptation.},
      keywords     = {Prognostic (Other) / Radiotherapy (Other) / Small cell lung
                      cancer (Other) / Treatment response (Other) /
                      [18F]FDG-PET/CT (Other)},
      cin          = {ED01},
      ddc          = {610},
      cid          = {I:(DE-He78)ED01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41247515},
      doi          = {10.1007/s00259-025-07658-5},
      url          = {https://inrepo02.dkfz.de/record/306257},
}