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000306345 037__ $$aDKFZ-2025-02561
000306345 041__ $$aEnglish
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000306345 1001_ $$aKunte, Sophie Carina$$b0
000306345 245__ $$aFeasibility of different meningioma delineation approaches on [18F]SiTATE PET/CT imaging.
000306345 260__ $$a[New York]$$bSpringer$$c2025
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000306345 500__ $$aVolume 16, article number 2189, (2025) 
000306345 520__ $$aBackground:Somatostatin receptor (SSTR)-targeted PET is valuable for meningioma imaging due to high SSTR expression. [18F]SiTATE, a novel tracer, is not only promising for imaging neuroendocrine tumors but also for meningiomas. Standardized delineation methods on [18F]SiTATE PET are lacking. This study correlates CT-based volumes with PET-based delineation approaches to identify a threshold for standardized [18F]SiTATE PET volume assessment.Methods:Patients with well-delineated, extraosseous meningioma on CT (≥ 1mL) who underwent [18F]SiTATE PET/CT were included. Volumes were assessed on contrast-enhanced CT and correlated with PET-based delineation approaches: (I) fixed SUV threshold, (II) isocontour thresholding relative to SUVmax (SUV%), and thresholds relative to (III) bone marrow (SUVBM), (IV) parotid gland (SUVparotis) and (V) pituitary gland (SUVsella).Results:19 meningiomas in 17 PET/CT scans (16 patients) were included. A fixed SUV of 4.0 (r = 0.783, p < 0.001) showed good correlation with CT volumes without skewed distribution on Bland-Altman-Plot analysis. Using isocontour-based thresholds, 45% SUVmax (r = 0.496, p = 0.031) showed the highest concordance. Best reference-based approaches were achieved by 150% SUVBM (r = 0.859, p < 0.001), 250% SUVparotis (r = 0.460, p = 0.047) and 70% SUVsella (r = 0.819, p < 0.001). However, background-based approaches showed a trend towards overestimation of PET-volumes in larger meningiomas as assessed on Bland-Altman-Plot analyses. Uptake intensities of reference tissues (SUVBM, SUVparotis and SUVsella) were not inter-correlated (p > 0.05 each).Conclusion:A fixed SUV threshold of 4.0 showed strong agreement with CT-based volumes in well-delineated, extraosseous meningiomas which offers a simple, clinically applicable method without technical requirements. Reference tissue-based methods showed similar correlations but tended to overestimate volumes in larger lesions.
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000306345 650_7 $$2Other$$aDelineation
000306345 650_7 $$2Other$$aIsocontour
000306345 650_7 $$2Other$$aMeningioma
000306345 650_7 $$2Other$$aSSTR
000306345 650_7 $$2Other$$aSUV
000306345 650_7 $$2Other$$a[18F]SiTATE
000306345 7001_ $$aUnterrainer, Lena M$$b1
000306345 7001_ $$aLindner, Simon$$b2
000306345 7001_ $$aHolzgreve, Adrien$$b3
000306345 7001_ $$aKunz, Wolfgang G$$b4
000306345 7001_ $$aWinkelmann, Michael$$b5
000306345 7001_ $$aNitschmann, Alexander$$b6
000306345 7001_ $$aJurkschat, Klaus$$b7
000306345 7001_ $$aWängler, Carmen$$b8
000306345 7001_ $$aWängler, Björn$$b9
000306345 7001_ $$aSchirrmacher, Ralf$$b10
000306345 7001_ $$0P:(DE-HGF)0$$aBelka, Claus$$b11
000306345 7001_ $$aThon, Niklas$$b12
000306345 7001_ $$aSchichor, Christian$$b13
000306345 7001_ $$aBartenstein, Peter$$b14
000306345 7001_ $$aUnterrainer, Marcus$$b15
000306345 773__ $$0PERI:(DE-600)3059869-2$$a10.1007/s12672-025-04079-6$$p2189$$tDiscover oncology$$v16$$x1868-8497$$y2025
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