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@ARTICLE{Kunte:306345,
      author       = {S. C. Kunte and L. M. Unterrainer and S. Lindner and A.
                      Holzgreve and W. G. Kunz and M. Winkelmann and A. Nitschmann
                      and K. Jurkschat and C. Wängler and B. Wängler and R.
                      Schirrmacher and C. Belka$^*$ and N. Thon and C. Schichor
                      and P. Bartenstein and M. Unterrainer},
      title        = {{F}easibility of different meningioma delineation
                      approaches on [18{F}]{S}i{TATE} {PET}/{CT} imaging.},
      journal      = {Discover oncology},
      volume       = {16},
      issn         = {1868-8497},
      address      = {[New York]},
      publisher    = {Springer},
      reportid     = {DKFZ-2025-02561},
      pages        = {2189},
      year         = {2025},
      note         = {Volume 16, article number 2189, (2025)},
      abstract     = {Background:Somatostatin receptor (SSTR)-targeted PET is
                      valuable for meningioma imaging due to high SSTR expression.
                      [18F]SiTATE, a novel tracer, is not only promising for
                      imaging neuroendocrine tumors but also for meningiomas.
                      Standardized delineation methods on [18F]SiTATE PET are
                      lacking. This study correlates CT-based volumes with
                      PET-based delineation approaches to identify a threshold for
                      standardized [18F]SiTATE PET volume
                      assessment.Methods:Patients with well-delineated,
                      extraosseous meningioma on CT (≥ 1mL) who underwent
                      [18F]SiTATE PET/CT were included. Volumes were assessed on
                      contrast-enhanced CT and correlated with PET-based
                      delineation approaches: (I) fixed SUV threshold, (II)
                      isocontour thresholding relative to SUVmax $(SUV\%),$ and
                      thresholds relative to (III) bone marrow (SUVBM), (IV)
                      parotid gland (SUVparotis) and (V) pituitary gland
                      (SUVsella).Results:19 meningiomas in 17 PET/CT scans (16
                      patients) were included. A fixed SUV of 4.0 (r = 0.783,
                      p < 0.001) showed good correlation with CT volumes
                      without skewed distribution on Bland-Altman-Plot analysis.
                      Using isocontour-based thresholds, $45\%$ SUVmax
                      (r = 0.496, p = 0.031) showed the highest
                      concordance. Best reference-based approaches were achieved
                      by $150\%$ SUVBM (r = 0.859, p < 0.001), $250\%$
                      SUVparotis (r = 0.460, p = 0.047) and $70\%$
                      SUVsella (r = 0.819, p < 0.001). However,
                      background-based approaches showed a trend towards
                      overestimation of PET-volumes in larger meningiomas as
                      assessed on Bland-Altman-Plot analyses. Uptake intensities
                      of reference tissues (SUVBM, SUVparotis and SUVsella) were
                      not inter-correlated (p > 0.05 each).Conclusion:A fixed
                      SUV threshold of 4.0 showed strong agreement with CT-based
                      volumes in well-delineated, extraosseous meningiomas which
                      offers a simple, clinically applicable method without
                      technical requirements. Reference tissue-based methods
                      showed similar correlations but tended to overestimate
                      volumes in larger lesions.},
      keywords     = {Delineation (Other) / Isocontour (Other) / Meningioma
                      (Other) / SSTR (Other) / SUV (Other) / [18F]SiTATE (Other)},
      cin          = {MU01},
      ddc          = {610},
      cid          = {I:(DE-He78)MU01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41258525},
      doi          = {10.1007/s12672-025-04079-6},
      url          = {https://inrepo02.dkfz.de/record/306345},
}