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| 001 | 306345 | ||
| 005 | 20260108124520.0 | ||
| 024 | 7 | _ | |a 10.1007/s12672-025-04079-6 |2 doi |
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| 024 | 7 | _ | |a 2730-6011 |2 ISSN |
| 037 | _ | _ | |a DKFZ-2025-02561 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Kunte, Sophie Carina |b 0 |
| 245 | _ | _ | |a Feasibility of different meningioma delineation approaches on [18F]SiTATE PET/CT imaging. |
| 260 | _ | _ | |a [New York] |c 2025 |b Springer |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1767872692_3506153 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a Volume 16, article number 2189, (2025) |
| 520 | _ | _ | |a Background:Somatostatin receptor (SSTR)-targeted PET is valuable for meningioma imaging due to high SSTR expression. [18F]SiTATE, a novel tracer, is not only promising for imaging neuroendocrine tumors but also for meningiomas. Standardized delineation methods on [18F]SiTATE PET are lacking. This study correlates CT-based volumes with PET-based delineation approaches to identify a threshold for standardized [18F]SiTATE PET volume assessment.Methods:Patients with well-delineated, extraosseous meningioma on CT (≥ 1mL) who underwent [18F]SiTATE PET/CT were included. Volumes were assessed on contrast-enhanced CT and correlated with PET-based delineation approaches: (I) fixed SUV threshold, (II) isocontour thresholding relative to SUVmax (SUV%), and thresholds relative to (III) bone marrow (SUVBM), (IV) parotid gland (SUVparotis) and (V) pituitary gland (SUVsella).Results:19 meningiomas in 17 PET/CT scans (16 patients) were included. A fixed SUV of 4.0 (r = 0.783, p < 0.001) showed good correlation with CT volumes without skewed distribution on Bland-Altman-Plot analysis. Using isocontour-based thresholds, 45% SUVmax (r = 0.496, p = 0.031) showed the highest concordance. Best reference-based approaches were achieved by 150% SUVBM (r = 0.859, p < 0.001), 250% SUVparotis (r = 0.460, p = 0.047) and 70% SUVsella (r = 0.819, p < 0.001). However, background-based approaches showed a trend towards overestimation of PET-volumes in larger meningiomas as assessed on Bland-Altman-Plot analyses. Uptake intensities of reference tissues (SUVBM, SUVparotis and SUVsella) were not inter-correlated (p > 0.05 each).Conclusion:A fixed SUV threshold of 4.0 showed strong agreement with CT-based volumes in well-delineated, extraosseous meningiomas which offers a simple, clinically applicable method without technical requirements. Reference tissue-based methods showed similar correlations but tended to overestimate volumes in larger lesions. |
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| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de |
| 650 | _ | 7 | |a Delineation |2 Other |
| 650 | _ | 7 | |a Isocontour |2 Other |
| 650 | _ | 7 | |a Meningioma |2 Other |
| 650 | _ | 7 | |a SSTR |2 Other |
| 650 | _ | 7 | |a SUV |2 Other |
| 650 | _ | 7 | |a [18F]SiTATE |2 Other |
| 700 | 1 | _ | |a Unterrainer, Lena M |b 1 |
| 700 | 1 | _ | |a Lindner, Simon |b 2 |
| 700 | 1 | _ | |a Holzgreve, Adrien |b 3 |
| 700 | 1 | _ | |a Kunz, Wolfgang G |b 4 |
| 700 | 1 | _ | |a Winkelmann, Michael |b 5 |
| 700 | 1 | _ | |a Nitschmann, Alexander |b 6 |
| 700 | 1 | _ | |a Jurkschat, Klaus |b 7 |
| 700 | 1 | _ | |a Wängler, Carmen |b 8 |
| 700 | 1 | _ | |a Wängler, Björn |b 9 |
| 700 | 1 | _ | |a Schirrmacher, Ralf |b 10 |
| 700 | 1 | _ | |a Belka, Claus |0 P:(DE-HGF)0 |b 11 |
| 700 | 1 | _ | |a Thon, Niklas |b 12 |
| 700 | 1 | _ | |a Schichor, Christian |b 13 |
| 700 | 1 | _ | |a Bartenstein, Peter |b 14 |
| 700 | 1 | _ | |a Unterrainer, Marcus |b 15 |
| 773 | _ | _ | |a 10.1007/s12672-025-04079-6 |0 PERI:(DE-600)3059869-2 |p 2189 |t Discover oncology |v 16 |y 2025 |x 1868-8497 |
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