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@ARTICLE{Cantarella:306533,
author = {S. Cantarella$^*$ and J. Neffe$^*$ and M. Hermes$^*$ and F.
Rauscher$^*$ and R. Schwarz$^*$ and P. Jaisankar$^*$ and E.
Schäfer$^*$ and M. Caudron-Herger$^*$},
title = {{RBP}2{GO} 2.0: {I}ntegrating disease associations and
sequence features to explore {RNA}-binding protein
functions.},
journal = {Nucleic acids research},
volume = {nn},
issn = {0305-1048},
address = {Oxford},
publisher = {Oxford Univ. Press},
reportid = {DKFZ-2025-02598},
pages = {nn},
year = {2025},
note = {ISSN 1362-4962 / #EA:B150#LA:B150# / epub},
abstract = {RNA-binding proteins (RBPs) play key roles in a wide range
of biological processes and human diseases. Here, we updated
RBP2GO, a comprehensive resource on RBPs, their binding
partners, and functions across 13 species. The database
RBP2GO 2.0 now provides additional information on disease
ontology to better relate RBP functions to their impact in
human diseases. It also integrates knowledge from new
proteome-wide RBP studies and provides specific information
on sequence features through intuitive cartoon-style
representations, such as associated RNA-binding peptides,
when available. Existing eCLIP/iCLIP datasets from ENCODE
have been linked to the corresponding proteins, along with
RNA dependence information from the R-DeeP database. Protein
characterization is further supported by two scores, the
RBP2GO Score and the RBP2GO Composite Score, which reflect
the probability that the protein binds to RNA. The scores
are now visualized using violin plot distributions for the
whole proteome of each species. The redesigned user
interface enables intuitive searches for protein names, gene
ontology terms, disease ontology terms, and protein domains
directly from the Home page and provides extended, versatile
search options via the Advanced Search module. RBP2GO 2.0
serves as a valuable tool for investigating new RBP
functions and is publicly accessible at
https://RBP2GOv2.dkfz.de.},
cin = {B150},
ddc = {570},
cid = {I:(DE-He78)B150-20160331},
pnm = {312 - Funktionelle und strukturelle Genomforschung
(POF4-312)},
pid = {G:(DE-HGF)POF4-312},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:41277526},
doi = {10.1093/nar/gkaf1258},
url = {https://inrepo02.dkfz.de/record/306533},
}