%0 Journal Article
%A White, Mark
%A Mills, Megan L
%A Millett, Laura M
%A Gilroy, Kathryn
%A Hong, Yourae
%A Zeiger, Lucas B
%A Simpson, Rosalin J
%A Corry, Shania M
%A Ligeza, Amelia
%A Lannagan, Tamsin R M
%A Susanti, Susanti
%A Ridgway, Rachel A
%A Yazgili, Ayse S
%A Grzesiak, Lucile
%A Amirkhah, Raheleh
%A Ford, Catriona A
%A Vlahov, Nikola
%A Tovell, Hannah
%A Officer-Jones, Leah
%A Ficken, Catherine
%A Pennie, Rachel
%A Najumudeen, Arafath K
%A Raven, Alexander
%A Nasreddin, Nadia
%A Chauhan, Ekansh
%A Papanastasiou, Andrew S
%A Nixon, Colin
%A Morrison, Vivienne
%A Jackstadt, Rene-Filip
%A Graham, Janet S
%A Miller, Crispin J
%A Ross, Sarah J
%A Barry, Simon T
%A Pavet, Valeria
%A Wilson, Richard H
%A Le Quesne, John
%A Dunne, Philip D
%A Tejpar, Sabine
%A Leedham, Simon
%A Campbell, Andrew D
%A Sansom, Owen J
%T MAPK-driven epithelial cell plasticity drives colorectal cancer therapeutic resistance.
%J Nature
%V 650
%N 8102
%@ 0028-0836
%C London [u.a.]
%I Nature Publ. Group
%M DKFZ-2025-02614
%P 748-758
%D 2026
%Z 2026 Feb;650(8102):748-758
%X The colorectal epithelium is rapidly renewing, with remarkable capacity to regenerate following injury. In colorectal cancer (CRC), this regenerative capacity can be co-opted to drive epithelial plasticity. While oncogenic MAPK signalling in CRC is common, with frequent mutations of both KRAS (40-50
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41286180
%R 10.1038/s41586-025-09916-w
%U https://inrepo02.dkfz.de/record/306549