%0 Journal Article
%A Shang, Fuwei
%A Nizharadze, Tamar
%A Thiele, Robin
%A Cirovic, Branko
%A Frank, Larissa Johanna
%A Busch, Katrin
%A Pei, Weike
%A Feyerabend, Thorsten
%A Höfer, Thomas
%A Wang, Xi
%A Rodewald, Hans-Reimer
%T Multipotent progenitors with distinct origins, clonal lineage fates, transcriptomes, and surface markers yield two hematopoietic trees.
%J Proceedings of the National Academy of Sciences of the United States of America
%V 122
%N 48
%@ 0027-8424
%C Washington, DC
%I National Acad. of Sciences
%M DKFZ-2025-02615
%P e2505510122
%D 2025
%Z #EA:D110#LA:D110#
%X Multipotent progenitors (MPP) are the quantitative source of native hematopoiesis that have been thought to be replenished slowly by hematopoietic stem cells (HSC). However, recent fate mapping studies have revealed two developmentally distinct populations of MPP, HSC-derived MPP (hMPP), and HSC-independent, embryonic MPP (eMPP). These data raise fundamental questions on the distinctions and functions of these progenitors. Here, we mapped the clonal dynamics of the two independent MPP systems, using in situ barcoding, and barcode linkage (hMPP), or disconnect (eMPP), with HSC. The cumulative output of eMPP to hematopoiesis was 35
%K Animals
%K Hematopoietic Stem Cells: cytology
%K Hematopoietic Stem Cells: metabolism
%K Cell Lineage
%K Mice
%K Transcriptome
%K Multipotent Stem Cells: cytology
%K Multipotent Stem Cells: metabolism
%K Hematopoiesis: physiology
%K Cell Differentiation
%K Biomarkers: metabolism
%K Mice, Inbred C57BL
%K barcoding (Other)
%K fate mapping (Other)
%K layers of hematopoiesis (Other)
%K stem and progenitor cells (Other)
%K surface marker identification (Other)
%K Biomarkers (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41284889
%R 10.1073/pnas.2505510122
%U https://inrepo02.dkfz.de/record/306550