TY  - JOUR
AU  - Shang, Fuwei
AU  - Nizharadze, Tamar
AU  - Thiele, Robin
AU  - Cirovic, Branko
AU  - Frank, Larissa Johanna
AU  - Busch, Katrin
AU  - Pei, Weike
AU  - Feyerabend, Thorsten
AU  - Höfer, Thomas
AU  - Wang, Xi
AU  - Rodewald, Hans-Reimer
TI  - Multipotent progenitors with distinct origins, clonal lineage fates, transcriptomes, and surface markers yield two hematopoietic trees.
JO  - Proceedings of the National Academy of Sciences of the United States of America
VL  - 122
IS  - 48
SN  - 0027-8424
CY  - Washington, DC
PB  - National Acad. of Sciences
M1  - DKFZ-2025-02615
SP  - e2505510122
PY  - 2025
N1  - #EA:D110#LA:D110#
AB  - Multipotent progenitors (MPP) are the quantitative source of native hematopoiesis that have been thought to be replenished slowly by hematopoietic stem cells (HSC). However, recent fate mapping studies have revealed two developmentally distinct populations of MPP, HSC-derived MPP (hMPP), and HSC-independent, embryonic MPP (eMPP). These data raise fundamental questions on the distinctions and functions of these progenitors. Here, we mapped the clonal dynamics of the two independent MPP systems, using in situ barcoding, and barcode linkage (hMPP), or disconnect (eMPP), with HSC. The cumulative output of eMPP to hematopoiesis was 35
KW  - Animals
KW  - Hematopoietic Stem Cells: cytology
KW  - Hematopoietic Stem Cells: metabolism
KW  - Cell Lineage
KW  - Mice
KW  - Transcriptome
KW  - Multipotent Stem Cells: cytology
KW  - Multipotent Stem Cells: metabolism
KW  - Hematopoiesis: physiology
KW  - Cell Differentiation
KW  - Biomarkers: metabolism
KW  - Mice, Inbred C57BL
KW  - barcoding (Other)
KW  - fate mapping (Other)
KW  - layers of hematopoiesis (Other)
KW  - stem and progenitor cells (Other)
KW  - surface marker identification (Other)
KW  - Biomarkers (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:41284889
DO  - DOI:10.1073/pnas.2505510122
UR  - https://inrepo02.dkfz.de/record/306550
ER  -