TY  - JOUR
AU  - Pabst, Kim M
AU  - Siegmund, Sophie C
AU  - Holzgreve, Adrien
AU  - Schmid, Hans P
AU  - Bartel, Timo
AU  - Herrmann, Ken
AU  - Küper, Alina T
AU  - Aydogdu, Can
AU  - Kersting, David
AU  - Kesch, Claudia
AU  - Hadaschik, Boris A
AU  - Unterrainer, Marcus
AU  - Stief, Christian G
AU  - Cyran, Clemens C
AU  - Werner, Rudolf A
AU  - Fendler, Wolfgang P
AU  - Casuscelli, Jozefina
AU  - Unterrainer, Lena M
TI  - Potential value of [68Ga]Ga-FAPI-46 PET in patients with metastatic urothelial carcinoma: a bi-centric analysis.
JO  - European journal of nuclear medicine and molecular imaging
VL  - nn
SN  - 1619-7070
CY  - Heidelberg [u.a.]
PB  - Springer-Verl.
M1  - DKFZ-2025-02626
SP  - nn
PY  - 2025
N1  - epub
AB  - [68Ga]Ga-FAPI-46 has shown promise for urothelial cancer (UC) detection. This study evaluates its diagnostic value versus contrast-enhanced CT (ceCT) and 2-[18F]FDG PET in the largest bi-centric cohort to date.Patients with metastatic UC undergoing [68Ga]Ga-FAPI-46 PET at University Hospitals Munich or Essen were retrospectively reviewed. Detection rates were compared with ceCT on a regional basis (primary, lymph nodes, visceral organs, bone). SUVmax and SUVmean of two index lesions were recorded. In a sub-cohort, [68Ga]Ga-FAPI-46 and 2-[18F]FDG PET were compared on a lesion basis. Clinical follow-up and/or histopathology served as reference.Thirty-four patients underwent [68Ga]Ga-FAPI-46 PET/CT and ceCT, including 10 (29
KW  - 2-[18F]FDG-PET (Other)
KW  - CeCT (Other)
KW  - Detection efficacy (Other)
KW  - Urothelial carcinoma (Other)
KW  - [68Ga]Ga-FAPI-46 PET (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:41288692
DO  - DOI:10.1007/s00259-025-07674-5
UR  - https://inrepo02.dkfz.de/record/306585
ER  -