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@ARTICLE{Amon:306606,
      author       = {L. Amon and D. Vurnek and A. Seichter and G. Tchitashvili
                      and T. Kaszubowski and M. Mroz and N. Debeuf and T. Vogler
                      and N. Küpper and K. R. Rengarajan and L. Lächele and N.
                      R. Tochoedo and A. Baranska and S. E. Autenrieth$^*$ and F.
                      Nimmerjahn and K. Hildner and K. Pfeffer and B. U. Schraml
                      and L. Heger and B. N. Lambrecht and C. H. K. Lehmann and D.
                      Dudziak},
      title        = {{GM}-{CSF} and specific type 2 cytokines induce {CD}103+
                      and {CD}301b+ cell states in c{DC}1s and c{DC}2s.},
      journal      = {Cell reports},
      volume       = {44},
      number       = {12},
      issn         = {2211-1247},
      address      = {Maryland Heights, MO},
      publisher    = {Cell Press},
      reportid     = {DKFZ-2025-02643},
      pages        = {116589},
      year         = {2025},
      abstract     = {The heterogeneity of conventional dendritic cells type 1
                      (cDC1s) and type 2 (cDC2s) is well established, yet the
                      identity and origin of CD301b+ cDC2s remain debated. Here,
                      we show that CD301b+ cDC2s and CD103+ cDC1s develop from
                      pre-committed progenitors in response to
                      granulocyte/macrophage colony-stimulating factor (GM-CSF).
                      While CD103+ cDC1s acquire their phenotype and functional
                      properties through GM-CSF-driven differentiation from
                      pre-cDC1s, CD301b+ cDC2s emerge as cytokine-induced states
                      from DC2- and DC3-committed progenitors. CD103+ cDC1s and
                      CD301b+ cDC2s exhibit enhanced T cell priming capacities and
                      distinct cytokine expression profiles upon GM-CSF exposure.
                      In vivo, DC-intrinsic GM-CSF sensing is dispensable for
                      acquiring CD103 and CD301b expression with the notable
                      exception of lung DCs, while specific type 2 cytokines
                      induce CD103 and CD301b ex vivo. These findings identify
                      GM-CSF and specific type 2 cytokines as central regulators
                      of cDC1 and cDC2 effector differentiation and establish
                      CD301b as a marker of a cytokine-driven cDC2 state.},
      keywords     = {CD103(+) cDC1 (Other) / CD301b (Other) / CD301b(+) cDC2
                      (Other) / CP: immunology (Other) / DC2 and DC3 progenitor
                      (Other) / GM-CSF (Other) / cell state (Other) / conventional
                      dendritic cells (Other) / heterogeneity (Other) / ontogeny
                      (Other) / type 2 cytokines (Other)},
      cin          = {D431},
      ddc          = {610},
      cid          = {I:(DE-He78)D431-20160331},
      pnm          = {314 - Immunologie und Krebs (POF4-314)},
      pid          = {G:(DE-HGF)POF4-314},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41307996},
      doi          = {10.1016/j.celrep.2025.116589},
      url          = {https://inrepo02.dkfz.de/record/306606},
}