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| Home > Publications database > GM-CSF and specific type 2 cytokines induce CD103+ and CD301b+ cell states in cDC1s and cDC2s. > print |
| Home > Publications database > GM-CSF and specific type 2 cytokines induce CD103+ and CD301b+ cell states in cDC1s and cDC2s. > print |
| 001 | 306606 | ||
| 005 | 20251129115931.0 | ||
| 024 | 7 | _ | |a 10.1016/j.celrep.2025.116589 |2 doi |
| 024 | 7 | _ | |a pmid:41307996 |2 pmid |
| 024 | 7 | _ | |a 2211-1247 |2 ISSN |
| 024 | 7 | _ | |a 2639-1856 |2 ISSN |
| 037 | _ | _ | |a DKFZ-2025-02643 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Amon, Lukas |b 0 |
| 245 | _ | _ | |a GM-CSF and specific type 2 cytokines induce CD103+ and CD301b+ cell states in cDC1s and cDC2s. |
| 260 | _ | _ | |a Maryland Heights, MO |c 2025 |b Cell Press |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1764338974_98055 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a The heterogeneity of conventional dendritic cells type 1 (cDC1s) and type 2 (cDC2s) is well established, yet the identity and origin of CD301b+ cDC2s remain debated. Here, we show that CD301b+ cDC2s and CD103+ cDC1s develop from pre-committed progenitors in response to granulocyte/macrophage colony-stimulating factor (GM-CSF). While CD103+ cDC1s acquire their phenotype and functional properties through GM-CSF-driven differentiation from pre-cDC1s, CD301b+ cDC2s emerge as cytokine-induced states from DC2- and DC3-committed progenitors. CD103+ cDC1s and CD301b+ cDC2s exhibit enhanced T cell priming capacities and distinct cytokine expression profiles upon GM-CSF exposure. In vivo, DC-intrinsic GM-CSF sensing is dispensable for acquiring CD103 and CD301b expression with the notable exception of lung DCs, while specific type 2 cytokines induce CD103 and CD301b ex vivo. These findings identify GM-CSF and specific type 2 cytokines as central regulators of cDC1 and cDC2 effector differentiation and establish CD301b as a marker of a cytokine-driven cDC2 state. |
| 536 | _ | _ | |a 314 - Immunologie und Krebs (POF4-314) |0 G:(DE-HGF)POF4-314 |c POF4-314 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de |
| 650 | _ | 7 | |a CD103(+) cDC1 |2 Other |
| 650 | _ | 7 | |a CD301b |2 Other |
| 650 | _ | 7 | |a CD301b(+) cDC2 |2 Other |
| 650 | _ | 7 | |a CP: immunology |2 Other |
| 650 | _ | 7 | |a DC2 and DC3 progenitor |2 Other |
| 650 | _ | 7 | |a GM-CSF |2 Other |
| 650 | _ | 7 | |a cell state |2 Other |
| 650 | _ | 7 | |a conventional dendritic cells |2 Other |
| 650 | _ | 7 | |a heterogeneity |2 Other |
| 650 | _ | 7 | |a ontogeny |2 Other |
| 650 | _ | 7 | |a type 2 cytokines |2 Other |
| 700 | 1 | _ | |a Vurnek, Damir |b 1 |
| 700 | 1 | _ | |a Seichter, Anna |b 2 |
| 700 | 1 | _ | |a Tchitashvili, Giorgi |b 3 |
| 700 | 1 | _ | |a Kaszubowski, Tomasz |b 4 |
| 700 | 1 | _ | |a Mroz, Markus |b 5 |
| 700 | 1 | _ | |a Debeuf, Nincy |b 6 |
| 700 | 1 | _ | |a Vogler, Tina |b 7 |
| 700 | 1 | _ | |a Küpper, Nicole |b 8 |
| 700 | 1 | _ | |a Rengarajan, Kaushikk Ravi |b 9 |
| 700 | 1 | _ | |a Lächele, Lukas |b 10 |
| 700 | 1 | _ | |a Tochoedo, Nounagnon R |b 11 |
| 700 | 1 | _ | |a Baranska, Anna |b 12 |
| 700 | 1 | _ | |a Autenrieth, Stella E |0 P:(DE-He78)d3dbba28fe1239effd15962787cbc363 |b 13 |u dkfz |
| 700 | 1 | _ | |a Nimmerjahn, Falk |b 14 |
| 700 | 1 | _ | |a Hildner, Kai |b 15 |
| 700 | 1 | _ | |a Pfeffer, Klaus |b 16 |
| 700 | 1 | _ | |a Schraml, Barbara U |b 17 |
| 700 | 1 | _ | |a Heger, Lukas |b 18 |
| 700 | 1 | _ | |a Lambrecht, Bart N |b 19 |
| 700 | 1 | _ | |a Lehmann, Christian H K |b 20 |
| 700 | 1 | _ | |a Dudziak, Diana |b 21 |
| 773 | _ | _ | |a 10.1016/j.celrep.2025.116589 |g Vol. 44, no. 12, p. 116589 - |0 PERI:(DE-600)2649101-1 |n 12 |p 116589 |t Cell reports |v 44 |y 2025 |x 2211-1247 |
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