TY  - JOUR
AU  - Zitricky, Frantisek
AU  - Sundquist, Kristina
AU  - Sundquist, Jan
AU  - Försti, Asta
AU  - Hemminki, Akseli
AU  - Hemminki, Kari
TI  - Second Primary Lung Cancer Associated With Family History of Lung Cancer.
JO  - Cancer medicine
VL  - 14
IS  - 23
SN  - 2045-7634
CY  - Hoboken, NJ
PB  - Wiley
M1  - DKFZ-2025-02665
SP  - e71431
PY  - 2025
N1  - #LA:C020# Z999
AB  - Familial clustering of initial primary lung cancer (IPLC) may be related to shared smoking habits, other environmental exposures and hereditary factors, but whether familial risk also influences the risk of second primary LC (SPLC) is not well known. We aimed to carry out a family study between first-degree relatives on SPLCs in Sweden.Population data on Swedish family relationships and the diagnosed cancers were obtained from the national registers from 1961 to 2021. IPLC was diagnosed in 54,429 patients of whom 534 were diagnosed with SPLC. Familial risk was assessed through the standardized incidence ratio (SIR with 95
KW  - Humans
KW  - Lung Neoplasms: epidemiology
KW  - Lung Neoplasms: genetics
KW  - Lung Neoplasms: pathology
KW  - Female
KW  - Male
KW  - Sweden: epidemiology
KW  - Middle Aged
KW  - Aged
KW  - Neoplasms, Second Primary: epidemiology
KW  - Neoplasms, Second Primary: genetics
KW  - Registries
KW  - Risk Factors
KW  - Incidence
KW  - Genetic Predisposition to Disease
KW  - Adult
KW  - Aged, 80 and over
KW  - adenocarcinoma (Other)
KW  - incidence trend (Other)
KW  - proband (Other)
KW  - sibling risk (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:41317095
C2  - pmc:PMC12664089
DO  - DOI:10.1002/cam4.71431
UR  - https://inrepo02.dkfz.de/record/306672
ER  -