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@ARTICLE{Zitricky:306672,
      author       = {F. Zitricky and K. Sundquist and J. Sundquist and A.
                      Försti$^*$ and A. Hemminki and K. Hemminki$^*$},
      title        = {{S}econd {P}rimary {L}ung {C}ancer {A}ssociated {W}ith
                      {F}amily {H}istory of {L}ung {C}ancer.},
      journal      = {Cancer medicine},
      volume       = {14},
      number       = {23},
      issn         = {2045-7634},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {DKFZ-2025-02665},
      pages        = {e71431},
      year         = {2025},
      note         = {#LA:C020# Z999},
      abstract     = {Familial clustering of initial primary lung cancer (IPLC)
                      may be related to shared smoking habits, other environmental
                      exposures and hereditary factors, but whether familial risk
                      also influences the risk of second primary LC (SPLC) is not
                      well known. We aimed to carry out a family study between
                      first-degree relatives on SPLCs in Sweden.Population data on
                      Swedish family relationships and the diagnosed cancers were
                      obtained from the national registers from 1961 to 2021. IPLC
                      was diagnosed in 54,429 patients of whom 534 were diagnosed
                      with SPLC. Familial risk was assessed through the
                      standardized incidence ratio (SIR with $95\%$ confidence
                      interval) adjusted for several potential confounders,
                      including sex, age, calendar period, educational level and
                      geographic region. Familial risks were analyzed by type of
                      proband, histology and sex. In addition, we estimated the
                      effect of family history on the cumulative proportion of
                      patients developing SPLC by sex and histology.The estimated
                      SIR for SPLC was 3.98 in patients without family history and
                      5.24 among those with a history of lung cancer in
                      first-degree relatives. The SIR values depended on the
                      histology of IPLC and of SPLC, with the highest SIRs for
                      concordant histologies. For the
                      adenocarcinoma-adenocarcinoma sequence, SIR estimates were
                      5.60 and 7.51 for non-familial and familial patients,
                      respectively. The familial risks were further modulated by
                      sex and type of affected relative, with the highest SIR for
                      females with affected mothers (9.14).The results showed a
                      positive association of family history of LC with risk of
                      SPLC on top of high risk for SPLC in non-familial patients.
                      The risks differed by sex, histology and type of affected
                      relative. The data on family history of LC should alert
                      about surveillance for SPLC and may be used in future risk
                      stratification when eligibility for population screening is
                      considered.},
      keywords     = {Humans / Lung Neoplasms: epidemiology / Lung Neoplasms:
                      genetics / Lung Neoplasms: pathology / Female / Male /
                      Sweden: epidemiology / Middle Aged / Aged / Neoplasms,
                      Second Primary: epidemiology / Neoplasms, Second Primary:
                      genetics / Registries / Risk Factors / Incidence / Genetic
                      Predisposition to Disease / Adult / Aged, 80 and over /
                      adenocarcinoma (Other) / incidence trend (Other) / proband
                      (Other) / sibling risk (Other)},
      cin          = {B062 / HD01 / C020},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)HD01-20160331 /
                      I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41317095},
      pmc          = {pmc:PMC12664089},
      doi          = {10.1002/cam4.71431},
      url          = {https://inrepo02.dkfz.de/record/306672},
}