TY  - JOUR
AU  - Looman, Esmée L
AU  - van Zon-Meijer, Tineke W H
AU  - Rühle, Alexander
AU  - Schäfer, Henning
AU  - Ludwig, Roman
AU  - Haas, Yoel Pérez
AU  - Langendijk, Johannes A
AU  - Guckenberger, Matthias
AU  - Balermpas, Panagiotis
AU  - Unkelbach, Jan
TI  - Patterns of lymphatic spread in hypopharyngeal squamous cell carcinoma - Findings from a multicenter study.
JO  - Radiotherapy and oncology
VL  - 214
SN  - 0167-8140
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DKFZ-2025-02669
SP  - 111319
PY  - 2026
N1  - Volume 214, January 2026, 111319
AB  - Aiming for personalization of the elective nodal irradiation (ENI) in hypopharyngeal squamous cell carcinoma (SCC) patients, we describe the regional lymphatic spread patterns and risk of lymph node metastases, considering not only T-stage, location and lateralization of the primary tumor, but also involvement of adjacent lymph node levels (LNLs).Patients with newly diagnosed hypopharyngeal SCC diagnosed at University Hospital Zurich between 2013-2021, UMCG Groningen between 2006-2023 and University Medical Center Freiburg between 2011-2019 were analyzed. Lymphatic involvement per level was assessed based on imaging and, if available, pathology. The dataset is made publicly available and can be visualized on https://lyprox.org/.390 patients with hypopharyngeal SCC were included, 81 
KW  - Hypopharynx (Other)
KW  - Lymphatic metastasis (Other)
KW  - Squamous cell carcinoma (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:41319718
DO  - DOI:10.1016/j.radonc.2025.111319
UR  - https://inrepo02.dkfz.de/record/306676
ER  -