%0 Journal Article
%A Tuorto, Francesca
%A Lyko, Frank
%T Microbial metabolites shape mammalian protein translation.
%J Cell metabolism
%V 37
%N 12
%@ 1550-4131
%C Amsterdam [u.a.]
%I Elsevier
%M DKFZ-2025-02736
%P 2301 - 2302
%D 2025
%Z #LA:A130# / DKFZ-ZMBH Alliance / Spotlight
%X Eukaryotic queuosine tRNA modification depends on the intake of microbial queuine. In a recent issue of Nature Cell Biology, Zhang et al. show that pre-queuosine 1 (preQ1), an intermediate of the bacterial queuine biosynthesis pathway, competes with queuine for the same mammalian tRNA targets to antagonistically modulate protein translation and cell proliferation.
%K Protein Biosynthesis
%K RNA, Transfer: metabolism
%K Humans
%K Animals
%K Nucleoside Q: metabolism
%K Nucleoside Q: analogs & derivatives
%K Nucleoside Q: biosynthesis
%K Bacteria: metabolism
%K Mammals: metabolism
%K RNA, Transfer (NLM Chemicals)
%K Nucleoside Q (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41338177
%R 10.1016/j.cmet.2025.11.003
%U https://inrepo02.dkfz.de/record/306752