%0 Journal Article
%A Sill, Martin
%A Schrimpf, Daniel
%A Patel, Areeba
%A Sturm, Dominik
%A Jäger, Natalie
%A Sievers, Philipp
%A Schweizer, Leonille
%A Banan, Rouzbeh
%A Reuss, David
%A Suwala, Abigail
%A Korshunov, Andrey
%A Stichel, Damian
%A Wefers, Annika K
%A Hau, Ann-Christin
%A Boldt, Henning
%A Harter, Patrick
%A Abdullaev, Zied
%A Benhamida, Jamal
%A Teichmann, Daniel
%A Koch, Arend
%A Hench, Jürgen
%A Frank, Stephan
%A Hasselblatt, Martin
%A Mansouri, Sheila
%A Díaz de Ståhl, Theresita
%A Serrano, Jonathan
%A Ecker, Jonas
%A Selt, Florian
%A Taylor, Michael
%A Ramaswamy, Vijay
%A Cavalli, Florence
%A Berghoff, Anna S
%A Bison, Brigitte
%A Blattner-Johnson, Mirjam
%A Buchhalter, Ivo
%A Buslei, Rolf
%A Calaminus, Gabriele
%A Dikow, Nicola
%A Dohmen, Hildegard
%A Euskirchen, Philipp
%A Fleischhack, Gudrun
%A Gajjar, Amar
%A Gerber, Nicolas U
%A Gessi, Marco
%A Gielen, Gerrit H
%A Gnekow, Astrid
%A Gottardo, Nicholas G
%A Haberler, Christine
%A Hamelmann, Stefan
%A Hans, Volkmar
%A Hansford, Jordan R
%A Hartmann, Christian
%A Heppner, Frank L
%A Driever, Pablo Hernaiz
%A von Hoff, Katja
%A Thomale, Ulrich W
%A Tippelt, Stephan
%A Frühwald, Michael C
%A Kramm, Christof M
%A Schüller, Ulrich
%A Schittenhelm, Jens
%A Schuhmann, Martin U
%A Stein, Marco
%A Ketteler, Petra
%A Ladanyi, Marc
%A Jabado, Nada
%A Jones, Barbara C
%A Jones, Chris
%A Karajannis, Matthias A
%A Ketter, Ralf
%A Kohlhof, Patricia
%A Kordes, Uwe
%A Reinhardt, Annekathrin
%A Kölsche, Christian
%A Lamszus, Katrin
%A Lichter, Peter
%A Maas, Sybren L N
%A Mawrin, Christian
%A Milde, Till
%A Mittelbronn, Michel
%A Monoranu, Camelia-Maria
%A Mueller, Wolf
%A Mynarek, Martin
%A Northcott, Paul A
%A Pajtler, Kristian W
%A Paulus, Werner
%A Perry, Arie
%A Blümcke, Ingmar
%A Plate, Karl H
%A Platten, Michael
%A Preusser, Matthias
%A Pietsch, Torsten
%A Prinz, Marco
%A Reifenberger, Guido
%A Kristensen, Bjarne W
%A Kool, Marcel
%A Hovestadt, Volker
%A Ellison, David W
%A Jacques, Thomas S
%A Varlet, Pascale
%A Etminan, Nima
%A Acker, Till
%A Weller, Michael
%A White, Christine L
%A Witt, Olaf
%A Herold-Mende, Christel
%A Debus, Jürgen
%A Krieg, Sandro
%A Wick, Wolfgang
%A Snuderl, Matija
%A Aldape, Ken
%A Brandner, Sebastian
%A Hawkins, Cynthia
%A Horbinski, Craig
%A Thomas, Christian
%A Wesseling, Pieter
%A von Deimling, Andreas
%A Capper, David
%A Pfister, Stefan M
%A Jones, David
%A Sahm, Felix
%T Advancing CNS tumor diagnostics with expanded DNA methylation-based classification.
%J Cancer cell
%V nn
%@ 1535-6108
%C Cambridge, Mass.
%I Cell Press
%M DKFZ-2025-02781
%P nn
%D 2025
%Z #EA:B062#LA:B300#LA:B360# / epub
%X DNA methylation-based classification is now central to contemporary neuro-oncology, as highlighted by the World Health Organization (WHO) classification of central nervous system (CNS) tumors. We present the Heidelberg CNS Tumor Methylation Classifier version 12.8 (v12.8), trained on 7,495 methylation profiles, which expands recognized entities from 91 classes in version 11 (v11) to 184 subclasses. This expansion is a result of newly identified tumor types discovered through our large online repository and global collaborations, underscoring CNS tumor heterogeneity. The random forest-based classifier achieves 95
%K CNS tumors (Other)
%K DNA methylation (Other)
%K MLOps (Other)
%K artificial intelligence (Other)
%K classification (Other)
%K epigenetics (Other)
%K machine learning (Other)
%K molecular diagnostics (Other)
%K precision medicine (Other)
%K tumor heterogeneity (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41349541
%R 10.1016/j.ccell.2025.11.002
%U https://inrepo02.dkfz.de/record/306804