TY  - JOUR
AU  - Guelen, Melisa S
AU  - Ferdowssian, Kiarash
AU  - Jung, Niklas
AU  - Celik, Hava N
AU  - Dell'Orco, Andrea
AU  - Eminovic, Semil
AU  - Früh, Anton
AU  - Samman, Majd
AU  - Acker, Güliz
AU  - Koch, Arend
AU  - Radbruch, Helena
AU  - Scheel, Michael
AU  - Wattjes, Mike P
AU  - Onken, Julia
AU  - Vajkoczy, Peter
AU  - Hecht, Nils
AU  - Nawabi, Jawed
AU  - Wasilewski, David
TI  - Outcomes and risk factors of hemorrhage in patients with resected brain metastases.
JO  - International journal of cancer
VL  - nn
SN  - 0020-7136
CY  - Bognor Regis
PB  - Wiley-Liss
M1  - DKFZ-2025-02835
SP  - nn
PY  - 2025
N1  - epub
AB  - Brain metastases (BrMs) may present with intralesional or intracranial hemorrhage (ICH), yet risk factors and outcomes remain unclear. This monocentric cohort study at Germany's largest neurosurgical clinic included 973 adults undergoing BrM resection (2010-2024), with histopathologically confirmed etiologies and known tumor burden. Based on pre-operative CT or MRI, 880 patients were categorized as non-hemorrhagic (non-hBrM), presenting with intralesional hemorrhage (hBrM), or with ICH of ≥30 mm diameter (ICH-BrM). Risk factors for hBrM and ICH-BrM were assessed, and overall survival (OS) and progression-free survival (PFS) were analyzed using Kaplan-Meyer methods. Of 880 patients, 560 (63.6
KW  - anticoagulants (Other)
KW  - hemorrhagic brain metastasis (Other)
KW  - intracranial hemorrhage (Other)
KW  - melanoma (Other)
KW  - survival (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:41355353
DO  - DOI:10.1002/ijc.70250
UR  - https://inrepo02.dkfz.de/record/306858
ER  -