TY  - JOUR
AU  - El-Marouk, Karim
AU  - Degerli, Esra
AU  - Käsmann, Lukas
AU  - Kröninger, Sophie
AU  - Kauffmann-Guerrero, Diego
AU  - Tufman, Amanda
AU  - Reinmuth, Niels
AU  - Duell, Thomas
AU  - Manapov, Farkhad
AU  - Belka, Claus
AU  - Eze, Chukwuka
AU  - Mansoorian, Sina
TI  - Long-term outcomes and patterns of failure after empiric SBRT for presumed early-stage lung tumors.
JO  - Frontiers in oncology
VL  - 15
SN  - 2234-943X
CY  - Lausanne
PB  - Frontiers Media
M1  - DKFZ-2025-02921
SP  - 1705311
PY  - 2025
AB  - Stereotactic body radiation therapy (SBRT) is the established standard of care for medically inoperable early-stage non-small cell lung cancer (ES-NSCLC). When a biopsy is unfeasible, it is often delivered empirically, yet long-term outcomes and failure patterns remain underreported.A total of 56 patients with clinically staged T1-T3N0M0 lung tumors treated with empiric SBRT (2011-2022) were retrospectively analyzed. Nineteen patients with recurrence were assessed for failure patterns and survival. Overall survival (OS), progression-free survival (PFS), local failure-free survival (LFFS), regional failure-free survival (RFFS), and distant metastasis-free survival (DMFS) were estimated using the Kaplan-Meier method. Competing risk analysis was performed with death treated as a competing event.At a median follow-up of 80.4 months (95
KW  - distant metastasis (Other)
KW  - early-stage non-small cell lung cancer (Other)
KW  - empiric SBRT (Other)
KW  - local control (Other)
KW  - presumed lung cancer (Other)
KW  - recurrence patterns (Other)
KW  - stereotactic body radiation therapy (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:41378286
C2  - pmc:PMC12687661
DO  - DOI:10.3389/fonc.2025.1705311
UR  - https://inrepo02.dkfz.de/record/306949
ER  -