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@ARTICLE{Laskar:307367,
      author       = {R. S. Laskar and N. Murphy and P. Ferrari and P. Brennan
                      and A. J. Cross and M. Guevara and V. Pala and K.
                      Smith-Byrne and A. Tjønneland and R. T. Fortner$^*$ and T.
                      B. Braaten and T. H. Nøst and G. Skeie and P. T. Campbell
                      and M. J. Gunter and K. B. Borch},
      title        = {{A} prospective investigation of early-onset colorectal
                      cancer risk factors-pooled analysis of three large-scale
                      {E}uropean cohorts.},
      journal      = {British journal of cancer},
      volume       = {nn},
      issn         = {0007-0920},
      address      = {Edinburgh},
      publisher    = {Nature Publ. Group},
      reportid     = {DKFZ-2025-03011},
      pages        = {nn},
      year         = {2025},
      note         = {epub},
      abstract     = {Colorectal cancer (CRC) incidence is rising among adults
                      under 55 years, but its causes remain unclear. Large-scale
                      prospective studies are needed to identify risk factors for
                      early-onset CRC (EOCRC).We pooled three large European
                      prospective cohort studies, examining 14 known or suspected
                      risk factors with EOCRC (diagnosed <55 years, N = 1369) and
                      later-onset CRCs (LOCRC) (diagnosed ≥55 years, N =
                      13,490). Cox proportional hazards models estimated hazard
                      ratios (HRs) and $95\%$ confidence intervals (CIs).Higher
                      body mass index (BMI, per 5 kg/m2 increase), was strongly
                      associated with EOCRC in men (HR 1.33, $95\%$ CI:
                      1.18-1.51), particularly for early-onset colon cancer (HR
                      1.55, $95\%$ CI: 1.32-1.82), compared to later-onset disease
                      (HR 1.25, $95\%$ CI: 1.19-1.31) (Phet = 0.01). Weaker
                      associations with BMI were observed for women and rectal
                      cancers. Similar sex and subsite specific trends were
                      observed for waist circumference and waist-to-hip ratio.
                      Current smoking (HR 1.24, $95\%$ CI: 1.07-1.44) and alcohol
                      use (HR 1.15, $95\%$ CI: 1.06-1.25) increased EOCRC risk,
                      and physical activity (HR 0.71, $95\%$ CI: 0.54-0.95) was
                      protective.Adiposity, physical inactivity, smoking, and
                      alcohol consumption are risk factors for EOCRC. Risk factors
                      were largely similar between EOCRC and LOCRC, except for
                      adiposity, with stronger EOCRC association in men.},
      cin          = {C180},
      ddc          = {610},
      cid          = {I:(DE-He78)C180-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41422343},
      doi          = {10.1038/s41416-025-03303-y},
      url          = {https://inrepo02.dkfz.de/record/307367},
}