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000307368 1001_ $$aRizzolo-Brime, Lucía$$b0
000307368 245__ $$aDietary nitrosyl-heme from processed meats and its association with colorectal cancer risk: findings from the EPIC cohort study.
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000307368 500__ $$a Volume 25, article number 14, (2026) / brief report
000307368 520__ $$aProcessed meat (PM) consumption is an established risk factor for colorectal cancer (CRC). It has been hypothesized that nitrosyl-heme, formed by the addition of nitrites during meat processing, may enhance the carcinogenic effects of PMs. This study aims to investigate the association between nitrosyl-heme intake and CRC risk within the European Prospective Investigation into Cancer and Nutrition(EPIC) study.This prospective study included 367,463 participants(70.3% women) from seven countries from the EPIC-study. Dietary data were collected via baseline questionnaires, and nitrosyl-heme exposure was estimated using biochemical data from 52 Spanish PMs, extrapolated to country-specific items. Sex-specific multivariable-adjusted hazard ratios(HRs) and 95% confidence intervals(CIs) were calculated using Cox proportional hazards models.Over a 15-year median follow-up, 5,115 incident CRC cases were identified. Comparing the highest vs. the lowest sex-specific tertile of nitrosyl-heme intake we found no significant association with CRC risk (HRT3vsT1:1.01;95%CI:0.93-1.09). Subgroup analyses by tumor subtype and interactions with lifestyle factors also showed no associations.This study offers insights into nitrosyl-heme exposure in European populations but found no link to CRC risk. Further research is needed to understand nitrosyl-heme's role in CRC.
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000307368 650_7 $$2Other$$aColorectal cancer
000307368 650_7 $$2Other$$aNitrosyl-heme
000307368 650_7 $$2Other$$aProcessed meat
000307368 7001_ $$aLujan-Barroso, Leila$$b1
000307368 7001_ $$aFarran-Codina, Andreu$$b2
000307368 7001_ $$aBou, Ricard$$b3
000307368 7001_ $$aNicolas, Genevieve$$b4
000307368 7001_ $$aHuybrechts, Inge$$b5
000307368 7001_ $$aLasheras, Cristina$$b6
000307368 7001_ $$aMontes, Esther Molina$$b7
000307368 7001_ $$aColorado-Yohar, Sandra$$b8
000307368 7001_ $$aGasque, Alba$$b9
000307368 7001_ $$aDahm, Christina C$$b10
000307368 7001_ $$aBock, Niels$$b11
000307368 7001_ $$aOlsen, Anja$$b12
000307368 7001_ $$aTjønneland, Anne$$b13
000307368 7001_ $$0P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4$$aKatzke, Verena$$b14$$udkfz
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000307368 7001_ $$aSchulze, Matthias B$$b16
000307368 7001_ $$aSaieva, Calogero$$b17
000307368 7001_ $$aSieri, Sabina$$b18
000307368 7001_ $$aDe Magistris, Maria Santucci$$b19
000307368 7001_ $$aTumino, Rosario$$b20
000307368 7001_ $$aMacciotta, Alessandra$$b21
000307368 7001_ $$aWareham, Nick$$b22
000307368 7001_ $$aWeiderpass, Elisabete$$b23
000307368 7001_ $$aChatziioannou, Chrysovalantou$$b24
000307368 7001_ $$aVineis, Paolo$$b25
000307368 7001_ $$00000-0003-0672-8847$$aJakszyn, Paula$$b26
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