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| Home > Publications database > Dietary nitrosyl-heme from processed meats and its association with colorectal cancer risk: findings from the EPIC cohort study. > print |
| Home > Publications database > Dietary nitrosyl-heme from processed meats and its association with colorectal cancer risk: findings from the EPIC cohort study. > print |
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| 041 | _ | _ | |a English |
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| 100 | 1 | _ | |a Rizzolo-Brime, Lucía |b 0 |
| 245 | _ | _ | |a Dietary nitrosyl-heme from processed meats and its association with colorectal cancer risk: findings from the EPIC cohort study. |
| 260 | _ | _ | |a London |c 2026 |b BioMed Central |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 500 | _ | _ | |a Volume 25, article number 14, (2026) / brief report |
| 520 | _ | _ | |a Processed meat (PM) consumption is an established risk factor for colorectal cancer (CRC). It has been hypothesized that nitrosyl-heme, formed by the addition of nitrites during meat processing, may enhance the carcinogenic effects of PMs. This study aims to investigate the association between nitrosyl-heme intake and CRC risk within the European Prospective Investigation into Cancer and Nutrition(EPIC) study.This prospective study included 367,463 participants(70.3% women) from seven countries from the EPIC-study. Dietary data were collected via baseline questionnaires, and nitrosyl-heme exposure was estimated using biochemical data from 52 Spanish PMs, extrapolated to country-specific items. Sex-specific multivariable-adjusted hazard ratios(HRs) and 95% confidence intervals(CIs) were calculated using Cox proportional hazards models.Over a 15-year median follow-up, 5,115 incident CRC cases were identified. Comparing the highest vs. the lowest sex-specific tertile of nitrosyl-heme intake we found no significant association with CRC risk (HRT3vsT1:1.01;95%CI:0.93-1.09). Subgroup analyses by tumor subtype and interactions with lifestyle factors also showed no associations.This study offers insights into nitrosyl-heme exposure in European populations but found no link to CRC risk. Further research is needed to understand nitrosyl-heme's role in CRC. |
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| 650 | _ | 7 | |a Colorectal cancer |2 Other |
| 650 | _ | 7 | |a Nitrosyl-heme |2 Other |
| 650 | _ | 7 | |a Processed meat |2 Other |
| 700 | 1 | _ | |a Lujan-Barroso, Leila |b 1 |
| 700 | 1 | _ | |a Farran-Codina, Andreu |b 2 |
| 700 | 1 | _ | |a Bou, Ricard |b 3 |
| 700 | 1 | _ | |a Nicolas, Genevieve |b 4 |
| 700 | 1 | _ | |a Huybrechts, Inge |b 5 |
| 700 | 1 | _ | |a Lasheras, Cristina |b 6 |
| 700 | 1 | _ | |a Montes, Esther Molina |b 7 |
| 700 | 1 | _ | |a Colorado-Yohar, Sandra |b 8 |
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| 700 | 1 | _ | |a Olsen, Anja |b 12 |
| 700 | 1 | _ | |a Tjønneland, Anne |b 13 |
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| 700 | 1 | _ | |a Schulze, Matthias B |b 16 |
| 700 | 1 | _ | |a Saieva, Calogero |b 17 |
| 700 | 1 | _ | |a Sieri, Sabina |b 18 |
| 700 | 1 | _ | |a De Magistris, Maria Santucci |b 19 |
| 700 | 1 | _ | |a Tumino, Rosario |b 20 |
| 700 | 1 | _ | |a Macciotta, Alessandra |b 21 |
| 700 | 1 | _ | |a Wareham, Nick |b 22 |
| 700 | 1 | _ | |a Weiderpass, Elisabete |b 23 |
| 700 | 1 | _ | |a Chatziioannou, Chrysovalantou |b 24 |
| 700 | 1 | _ | |a Vineis, Paolo |b 25 |
| 700 | 1 | _ | |a Jakszyn, Paula |0 0000-0003-0672-8847 |b 26 |
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