%0 Journal Article
%A Zimmermann, Noah
%A Kött, Julian
%A Zell, Tim
%A Abedini, Ali Zeinal
%A Blomen, Chiara L
%A Belz, Stella
%A Deitert, Benjamin
%A Heidrich, Isabel
%A Geidel, Glenn
%A Rünger, Alessandra
%A Smit, Daniel J
%A Weichenthal, Michael
%A Ugurel, Selma
%A Leiter, Ulrike
%A Berking, Carola
%A Gutzmer, Ralf
%A Schadendorf, Dirk
%A von Wasielewski, Imke
%A Mohr, Peter
%A Meier, Friedegund
%A Herbst, Rudolf
%A Utikal, Jochen
%A Terheyden, Patrick
%A Haferkamp, Sebastian
%A Pföhler, Claudia
%A Kaatz, Martin
%A Ziller, Fabian
%A Ulrich, Jens
%A Meiss, Frank
%A Bauer, Alexander T
%A Schneider, Stefan W
%A Gebhardt, Christoffer
%T Enhanced overall and progression-free survival in advanced melanoma patients undergoing targeted therapy alongside antithrombotic treatment - Insights from a multicenter study involving 1296 patients from the prospective skin cancer registry ADOReg.
%J European journal of cancer
%V 234
%@ 0959-8049
%C Amsterdam [u.a.]
%I Elsevier
%M DKFZ-2025-03059
%P 116195
%D 2026
%Z 2025 Dec 19:234:116195 / Available online 19 December 2025
%X Targeted therapies (TT) improve outcomes in BRAF-mutant melanoma. Pre-clinical data suggest that anticoagulation (AC) and platelet aggregation inhibition (PAI) may have antitumoral effects. We evaluated the impact of concomitant AC or PAI on outcomes in patients receiving TT.We analyzed 1296 patients with unresectable stage III-IV BRAF-mutant melanoma treated with BRAF plus MEK inhibitors (2016-2024) in the prospective multicenter ADOReg registry. Patients were categorized as receiving no antithrombotic therapy (ATT; n = 1125), PAI (n = 73; acetylsalicylic acid or clopidogrel), or AC (n = 98; direct oral anticoagulants, low-molecular-weight heparin, or vitamin K antagonists).Median follow-up was 1.3 years. Compared with patients without ATT, those receiving AC had significantly improved 12-month progression-free survival (PFS; HR 0.55, 95 
%K Anticoagulation (Other)
%K Melanoma (Other)
%K Targeted therapy (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41448065
%R 10.1016/j.ejca.2025.116195
%U https://inrepo02.dkfz.de/record/307460