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000307512 1001_ $$00000-0002-6596-456X$$aScheffler, Pierre$$b0
000307512 245__ $$aArtificial intelligence-based analysis and diagnosis of intradural extramedullary spinal tumors by stimulated Raman histology.
000307512 260__ $$aOxford$$bOxford University Press$$c2025
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000307512 520__ $$aIntraoperative Stimulated Raman Histology (SRH) has been reported to be fast and accurate in the assessment of neuro-oncological lesions. However, its application to spinal tumors, especially intradural extramedullary tumors (IDEM), remains underexplored. IDEM primarily include meningiomas and schwannomas, as well as less common entities such as metastases or ependymomas. Given that surgical resection is the primary treatment modality, rapid, artificial intelligence (AI)-driven intraoperative tumor classification based on SRH could enhance surgical decision-making and subsequent management.We acquired 232 SRH images from patients with IDEM using the NIO Laser Imaging System (Invenio Imaging Inc.). We categorized images into three diagnostic classes: 'Meningioma,' 'Schwannoma,' and 'Other.' Images were divided into 224 × 224 pixel patches and used to train and test AI-based image classifiers employing CTransPath, ResNet, and Vision Transformer architectures.Our best-performing model, utilizing the CTransPath architecture, achieved a classification accuracy of 94.3% on the test dataset. Vision Transformer-based models also performed well, exceeding 90% accuracy, while ResNet models attained slightly lower accuracies (79.6%-88.8%). Qualitative analysis indicates that the top-performing model primarily relies on cellular morphology for classification.Our findings confirm the feasibility and effectiveness of AI-assisted SRH analysis for distinguishing IDEM tumor types. This approach may complement conventional intraoperative neuropathology by providing rapid, reliable, and clinically actionable diagnostic information.
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000307512 650_7 $$2Other$$aartificial intelligence
000307512 650_7 $$2Other$$aintradural extramedullary tumors
000307512 650_7 $$2Other$$astimulated raman histology
000307512 7001_ $$0P:(DE-HGF)0$$aNeidert, Nicolas$$b1
000307512 7001_ $$aStraehle, Jakob$$b2
000307512 7001_ $$aErny, Daniel$$b3
000307512 7001_ $$00000-0002-0349-1955$$aPrinz, Marco$$b4
000307512 7001_ $$aHubbe, Ulrich$$b5
000307512 7001_ $$aRölz, Roland$$b6
000307512 7001_ $$aHeiland, Dieter Henrik$$b7
000307512 7001_ $$aBeck, Jürgen$$b8
000307512 7001_ $$00000-0002-8250-5883$$aEl Rahal, Amir$$b9
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